Associations between the FAS-670 A/G,-1377 G/A, and FASL-844 T/C polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-09-03T22:29:43Z | - |
dc.date.available | 2021-09-03T22:29:43Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88240 | - |
dc.description.abstract | Objective The aim of this study was to determine whether the FAS, and FASL polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). Methods A meta-analysis was conducted on the associations between the FAS -670 AIG, FAS-1377 GIA, and FASL-844 TIC polymorphisms and SLE. Results A total of eleven articles met the study inclusion criteria. Meta-analysis indicated an association between SLE and the FAS-670 AIG polymorphism in the dominant model (OR=0.629, 95% CI=0.409-0.967, p=0.035). Stratification by ethnicity indicated an association between the FAS-670 GG+GA genotype and SLE in Asian populations (OR=0.464, 95% CI=0.218-0.988, p=0.046). Meta-analysis indicated an association between SLE and the FAS-1377 AA+AG genotype (OR=0.712, 95% CI=0.528 - 0.961, p=0.027), and an association between SLE and the FASL +844 C allele was found (OR=1.377, 95% CI=1.162 - 1.633, p=2.3x10(-4)). Meta-analyses using the recessive model or homozygote contrast showed the same pattern as the meta-analysis of the FASL +844 C allele, that is, a significant association with SLE. Conclusion This meta-analysis demonstrates that the FAS-670 AIG, FAS-1377 GIA, and FASL-844 TIC polymorphisms are associated with susceptibility to SLE. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CLINICAL & EXPER RHEUMATOLOGY | - |
dc.subject | FAS GENE POLYMORPHISMS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | APO-1/FAS PROMOTER | - |
dc.subject | APOPTOSIS | - |
dc.subject | POPULATION | - |
dc.subject | SCLEROSIS | - |
dc.subject | REGION | - |
dc.subject | RISK | - |
dc.subject | SLE | - |
dc.subject | A/G | - |
dc.title | Associations between the FAS-670 A/G,-1377 G/A, and FASL-844 T/C polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.contributor.affiliatedAuthor | Song, G. G. | - |
dc.identifier.scopusid | 2-s2.0-84984804345 | - |
dc.identifier.wosid | 000383927800010 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.34, no.4, pp.634 - 640 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 634 | - |
dc.citation.endPage | 640 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | FAS GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | APO-1/FAS PROMOTER | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | SCLEROSIS | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordPlus | A/G | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordAuthor | FAS | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
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