Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules
DC Field | Value | Language |
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dc.contributor.author | Park, Yoon-Kyung | - |
dc.contributor.author | Jung, Sundo | - |
dc.contributor.author | Park, Se-Ho | - |
dc.date.accessioned | 2021-09-03T22:37:59Z | - |
dc.date.available | 2021-09-03T22:37:59Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-06-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88293 | - |
dc.description.abstract | In murine collagen-induced arthritis (CIA), self-reactive T cells can recognize peptide antigens derived from type-II collagen (CII). Activation of T cells is an important mediator of autoimmune diseases. Thus, T cells have become a focal point of study to treat autoimmune diseases. In this study, we evaluated the efficacy of recombinant MHC class II molecules in the regulation of antigen-specific T cells by using a self peptide derived from CII (CII260-274; IAGFKGEQGPKGEPG) linked to mouse I-A(q) in a murine CIA model. We found that recombinant I-A(q)/CII260-274 molecules could be recognized by CII-specific T cells and inhibit the same T cells in vitro. Furthermore, the development of CIA in mice was successfully prevented by in vivo injection of recombinant I-A(q)/CII260-274 molecules. Thus, treatment with recombinant soluble MHC class II molecules in complex with an immunodominant self-peptide might offer a potential therapeutic for chronic inflammation in autoimmune disease such as rheumatoid arthritis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | T-CELL-ACTIVATION | - |
dc.subject | INDUCED ARTHRITIS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | APOPTOSIS | - |
dc.subject | LIGANDS | - |
dc.subject | COMPLEX | - |
dc.subject | ANERGY | - |
dc.subject | MICE | - |
dc.subject | TETRAMERS | - |
dc.subject | THERAPY | - |
dc.title | Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.6.207 | - |
dc.identifier.scopusid | 2-s2.0-84991388054 | - |
dc.identifier.wosid | 000384755400006 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.49, no.6, pp.331 - 336 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 331 | - |
dc.citation.endPage | 336 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002118643 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | T-CELL-ACTIVATION | - |
dc.subject.keywordPlus | INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | ANERGY | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | TETRAMERS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Collagen-induced arthritis | - |
dc.subject.keywordAuthor | Immunotherapy | - |
dc.subject.keywordAuthor | Rheumatoid arthriti | - |
dc.subject.keywordAuthor | Recombinant MHC II | - |
dc.subject.keywordAuthor | Type-II collagen | - |
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