Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hwa Young | - |
dc.contributor.author | Lee, Geum-Hwa | - |
dc.contributor.author | Bhattarai, Kashi Raj | - |
dc.contributor.author | Park, Byung-Hyun | - |
dc.contributor.author | Koo, Seung-Hoi | - |
dc.contributor.author | Kim, Hyung-Ryong | - |
dc.contributor.author | Chae, Han Jung | - |
dc.date.accessioned | 2021-09-03T22:53:34Z | - |
dc.date.available | 2021-09-03T22:53:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-06-14 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88340 | - |
dc.description.abstract | In this study, we explored the effects of Bax Inhibitor-1 (BI-1) on ApoB aggregation in high-fat diet (HFD)-induced hepatic lipid accumulation. After 1 week on a HFD, triglycerides and cholesterol accumulated more in the liver and were not effectively secreted into the plasma, whereas after 8 weeks, lipids were highly accumulated in both the liver and plasma, with a greater effect in BI-1 KO mice compared with BI-1 WT mice. ApoB, a lipid transfer protein, was accumulated to a greater extent in the livers of HFD-BI-1 KO mice compared with HFD-BI-1 WT mice. Excessive post-translational oxidation of protein disulfide isomerase (PDI), intra-ER ROS accumulation and folding capacitance alteration were also observed in HFD-BI-1 KO mice. Higher levels of endoplasmic reticulum (ER) stress were consistently observed in KO mice compared with the WT mice. Adenovirus-mediated hepatic expression of BI-1 in the BI-1 KO mice rescued the above phenotypes. Our results suggest that BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation, likely through regulation of ER stress and ROS accumulation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | PROTEIN DISULFIDE-ISOMERASE | - |
dc.subject | FATTY LIVER-DISEASE | - |
dc.subject | ER-STRESS | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | BINDING PROTEIN | - |
dc.subject | QUALITY-CONTROL | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | DEGRADATION | - |
dc.subject | STEATOSIS | - |
dc.title | Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koo, Seung-Hoi | - |
dc.identifier.doi | 10.1038/srep27799 | - |
dc.identifier.scopusid | 2-s2.0-84974803229 | - |
dc.identifier.wosid | 000377750600001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | PROTEIN DISULFIDE-ISOMERASE | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | ER-STRESS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | STEATOSIS | - |
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