Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Hyeonjeong | - |
dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Lee, Yeong Mi | - |
dc.contributor.author | Kim, Jinhwan | - |
dc.contributor.author | Choi, Hyung Woo | - |
dc.contributor.author | Lee, Junseok | - |
dc.contributor.author | Park, Hyeongmok | - |
dc.contributor.author | Kang, Youngnam | - |
dc.contributor.author | Kim, In-San | - |
dc.contributor.author | Lee, Byung-Heon | - |
dc.contributor.author | Hoffman, Allan S. | - |
dc.contributor.author | Kim, Won Jong | - |
dc.date.accessioned | 2021-09-03T22:55:52Z | - |
dc.date.available | 2021-09-03T22:55:52Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-06-10 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88347 | - |
dc.description.abstract | This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, beta-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between beta-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | IRON-OXIDE NANOPARTICLES | - |
dc.subject | BETA-CYCLODEXTRIN | - |
dc.subject | IN-VIVO | - |
dc.subject | CANCER THERAPEUTICS | - |
dc.subject | ANTICANCER DRUG | - |
dc.subject | THERAPY | - |
dc.subject | PACLITAXEL | - |
dc.subject | RELEASE | - |
dc.subject | CARRIER | - |
dc.subject | TUMORS | - |
dc.title | Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-San | - |
dc.identifier.doi | 10.1016/j.jconrel.2016.01.006 | - |
dc.identifier.scopusid | 2-s2.0-84954306031 | - |
dc.identifier.wosid | 000376444600008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.231, pp.68 - 76 | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 231 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 76 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | BETA-CYCLODEXTRIN | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CANCER THERAPEUTICS | - |
dc.subject.keywordPlus | ANTICANCER DRUG | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CARRIER | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordAuthor | Multivalent host-guest chemistry | - |
dc.subject.keywordAuthor | Paclitaxel | - |
dc.subject.keywordAuthor | Cyclodextrin | - |
dc.subject.keywordAuthor | SPION | - |
dc.subject.keywordAuthor | Magnetic-guided drug delivery | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.