Serum Anion Gap Predicts All-Cause Mortality in Patients with Advanced Chronic Kidney Disease: A Retrospective Analysis of a Randomized Controlled Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Woo | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Cha, Ran-hui | - |
dc.contributor.author | Kang, Shin Wook | - |
dc.contributor.author | Park, Cheol Whee | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.contributor.author | Kim, Sung Gyun | - |
dc.contributor.author | Yoon, Sun Ae | - |
dc.contributor.author | Han, Sang Youb | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Chang, Jae Hyun | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.contributor.author | Kim, Yon Su | - |
dc.date.accessioned | 2021-09-03T23:03:11Z | - |
dc.date.available | 2021-09-03T23:03:11Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-06-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88373 | - |
dc.description.abstract | Background and Objectives Cardiovascular outcomes and mortality rates are poor in advanced chronic kidney disease (CKD) patients. Novel risk factors related to clinical outcomes should be identified. Methods A retrospective analysis of data from a randomized controlled study was performed in 440 CKD patients aged > 18 years, with estimated glomerular filtration rate 15-60 mL/min/1.73m(2). Clinical data were available, and the albumin-adjusted serum anion gap (A-SAG) could be calculated. The outcome analyzed was all-cause mortality. Results Of 440 participants, the median (interquartile range, IQR) follow-up duration was 5.1 (3.0-5.5) years. During the follow-up duration, 29 participants died (all-cause mortality 6.6%). The area under the receiver operating characteristic curve of A-SAG for all-cause mortality was 0.616 (95% CI 0.520-0.712, P = 0.037). The best threshold of A-SAG for all-cause mortality was 9.48 mmol/L, with sensitivity 0.793 and specificity 0.431. After adjusting for confounders, A-SAG above 9.48 mmol/L was independently associated with increased risk of all-cause mortality, with hazard ratio 2.968 (95% CI 1.143-7.708, P = 0.025). In our study, serum levels of beta-2 microglobulin and blood urea nitrogen (BUN) were positively associated with A-SAG. Conclusions A-SAG is an independent risk factor for all-cause mortality in advanced CKD patients. The positive correlation between A-SAG and serum beta-2 microglobulin or BUN might be a potential reason. Future study is needed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | NUTRITION EXAMINATION SURVEY | - |
dc.subject | NATIONAL-HEALTH | - |
dc.subject | ELDERLY POPULATION | - |
dc.subject | UREMIC TOXINS | - |
dc.subject | CYSTATIN-C | - |
dc.subject | BETA(2)-MICROGLOBULIN | - |
dc.subject | HEMODIALYSIS | - |
dc.subject | BICARBONATE | - |
dc.subject | PROTEIN | - |
dc.subject | ADULTS | - |
dc.title | Serum Anion Gap Predicts All-Cause Mortality in Patients with Advanced Chronic Kidney Disease: A Retrospective Analysis of a Randomized Controlled Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, Dae Ryong | - |
dc.identifier.doi | 10.1371/journal.pone.0156381 | - |
dc.identifier.scopusid | 2-s2.0-84973885432 | - |
dc.identifier.wosid | 000377184700040 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.11, no.6 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NUTRITION EXAMINATION SURVEY | - |
dc.subject.keywordPlus | NATIONAL-HEALTH | - |
dc.subject.keywordPlus | ELDERLY POPULATION | - |
dc.subject.keywordPlus | UREMIC TOXINS | - |
dc.subject.keywordPlus | CYSTATIN-C | - |
dc.subject.keywordPlus | BETA(2)-MICROGLOBULIN | - |
dc.subject.keywordPlus | HEMODIALYSIS | - |
dc.subject.keywordPlus | BICARBONATE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ADULTS | - |
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