Association between interferon-gamma+874 T/A polymorphism and susceptibility to autoimmune diseases: a meta-analysis
- Authors
- Lee, Y. H.; Bae, S-C
- Issue Date
- 6월-2016
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Autoimmune diseases; IFN; polymorphism; meta-analysis
- Citation
- LUPUS, v.25, no.7, pp.710 - 718
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUPUS
- Volume
- 25
- Number
- 7
- Start Page
- 710
- End Page
- 718
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88418
- DOI
- 10.1177/0961203315624557
- ISSN
- 0961-2033
- Abstract
- Objective The aim of this study was to explore whether the interferon (IFN)- +874 T/A polymorphism plays a role in modifying the risk of autoimmune diseases. Methods A meta-analysis was conducted on the association between the IFN- +874 T/A polymorphism and autoimmune diseases. Results Eighteen studies with a total of 2952 patients and 3832 controls were included in the meta-analysis. The meta-analysis revealed no association between autoimmune diseases and the IFN- +874 T allele in all study subjects (odds ratio (OR)=1.023, 95% confidence interval (CI)=0.894-1.171, p=0.738), but stratification by ethnicity indicated an association between the IFN- +874 T allele and autoimmune diseases in Latin American subjects (OR=0.780, 95% CI=0.629-0.953, p=0.015). Meta-analysis also revealed an association between autoimmune diseases and the IFN- +874 T/A polymorphism in Caucasian and Middle Eastern subjects under a dominant inheritance model (OR=0.686, 95% CI=0.489-0.964, p=0.003; OR=1.414, 95% CI=1.102-1.813, p=0.006). Meta-analysis by autoimmune disease type indicated an association between ITP and the IFN- +874 T allele (OR=1.753, 95% CI=1.228-2.503, p=0.002), but not for vasculitis, vitiligo, and auto-immune thyroid disease. Meta-analysis also showed a significant association between the IFN- +874 T/A polymorphism and systemic lupus erythematosus (SLE) under the dominant model (OR=1.668, 95% CI=1.114-2.497, p=0.013). Conclusions This meta-analysis indicates that the IFN- +874 T/A polymorphism may play a significant role in modifying the risk of autoimmune diseases in Caucasian, Latin American, and Middle Eastern subjects, and in particular shows that the IFN- +874 T/A polymorphism is associated with increased genetic susceptibility to idiopathic thrombocytopenic purpura and SLE.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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