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Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

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dc.contributor.authorJin, Qinghao-
dc.contributor.authorLee, Jin Woo-
dc.contributor.authorJang, Hari-
dc.contributor.authorChoi, Ji Eun-
dc.contributor.authorLee, Dongho-
dc.contributor.authorHong, Jin Tae-
dc.contributor.authorKim, Youngsoo-
dc.contributor.authorLee, Mi Kyeong-
dc.contributor.authorHwang, Bang Yeon-
dc.date.accessioned2021-09-03T23:35:50Z-
dc.date.available2021-09-03T23:35:50Z-
dc.date.created2021-06-18-
dc.date.issued2016-06-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/88599-
dc.description.abstractEight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 mu M.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subjectNF-KAPPA-B-
dc.subjectPOTENTIAL ANTIINFLAMMATORY AGENTS-
dc.subjectINDUCED NO PRODUCTION-
dc.subjectRAW264.7 CELLS-
dc.subjectINOS EXPRESSION-
dc.subjectGENUS INULA-
dc.subjectLACTONES-
dc.subjectBRITANNICA-
dc.subjectEUDESMANOLIDES-
dc.subjectGUAIANOLIDES-
dc.titleSesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1021/acs.jnatprod.5b01106-
dc.identifier.scopusid2-s2.0-84976438584-
dc.identifier.wosid000378758200009-
dc.identifier.bibliographicCitationJOURNAL OF NATURAL PRODUCTS, v.79, no.6, pp.1548 - 1553-
dc.relation.isPartOfJOURNAL OF NATURAL PRODUCTS-
dc.citation.titleJOURNAL OF NATURAL PRODUCTS-
dc.citation.volume79-
dc.citation.number6-
dc.citation.startPage1548-
dc.citation.endPage1553-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusPOTENTIAL ANTIINFLAMMATORY AGENTS-
dc.subject.keywordPlusINDUCED NO PRODUCTION-
dc.subject.keywordPlusRAW264.7 CELLS-
dc.subject.keywordPlusINOS EXPRESSION-
dc.subject.keywordPlusGENUS INULA-
dc.subject.keywordPlusLACTONES-
dc.subject.keywordPlusBRITANNICA-
dc.subject.keywordPlusEUDESMANOLIDES-
dc.subject.keywordPlusGUAIANOLIDES-
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