Synthesis of 2-Aryl-Substituted Indole-3-acetic Acid Derivatives via Intramolecular Imino-Stetter Reaction of Aldimines with Cyanide
DC Field | Value | Language |
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dc.contributor.author | Lee, Seong Jong | - |
dc.contributor.author | Seo, Hong-Ahn | - |
dc.contributor.author | Cheon, Cheol-Hong | - |
dc.date.accessioned | 2021-09-03T23:50:09Z | - |
dc.date.available | 2021-09-03T23:50:09Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05-19 | - |
dc.identifier.issn | 1615-4150 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88632 | - |
dc.description.abstract | A general method to generate umpolung of aldimines with cyanide was developed via the addition of cyanide to aldimines followed by a proton transfer from the carbon atom to the nitrogen atom in the resulting cyanide adducts. This novel method was successfully applied to the first imino-Stetter reaction of aldimines obtained from 2-aminocinnamic acid derivatives and aromatic aldehydes with cyanide, affording 2-aryl-substituted indole-3-acetic acid derivatives. Furthermore, the usefulness of this method was successfully demonstrated by the synthesis of an FPTase inhibitor, one of the biologically important 2-arylindole-3-acetic acid derivatives. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | INDOLE SYNTHESIS | - |
dc.title | Synthesis of 2-Aryl-Substituted Indole-3-acetic Acid Derivatives via Intramolecular Imino-Stetter Reaction of Aldimines with Cyanide | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cheon, Cheol-Hong | - |
dc.identifier.doi | 10.1002/adsc.201600155 | - |
dc.identifier.scopusid | 2-s2.0-84963537981 | - |
dc.identifier.wosid | 000377268100004 | - |
dc.identifier.bibliographicCitation | ADVANCED SYNTHESIS & CATALYSIS, v.358, no.10, pp.1566 - 1570 | - |
dc.relation.isPartOf | ADVANCED SYNTHESIS & CATALYSIS | - |
dc.citation.title | ADVANCED SYNTHESIS & CATALYSIS | - |
dc.citation.volume | 358 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1566 | - |
dc.citation.endPage | 1570 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | INDOLE SYNTHESIS | - |
dc.subject.keywordAuthor | aldimines | - |
dc.subject.keywordAuthor | 2-arylindole-3-acetic acid derivatives | - |
dc.subject.keywordAuthor | cyanide | - |
dc.subject.keywordAuthor | imino-Stetter reaction | - |
dc.subject.keywordAuthor | umpolung | - |
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