Aspirin resistance is associated with increased stroke severity and infarct volume
DC Field | Value | Language |
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dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Lee, Ju-Hun | - |
dc.contributor.author | Jung, San | - |
dc.contributor.author | Kim, Chulho | - |
dc.contributor.author | Jang, Min Uk | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.date.accessioned | 2021-09-03T23:54:22Z | - |
dc.date.available | 2021-09-03T23:54:22Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05-10 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88664 | - |
dc.description.abstract | Objectives: To investigate whether aspirin resistance is associated with initial stroke severity and infarct volume, using diffusion-weighted imaging (DWI) in patients with acute ischemic stroke that occurred while taking aspirin. Methods: We studied a total of 310 patients who were admitted within 48 hours of acute ischemic stroke onset. All patients had been taking aspirin for at least 7 days before stroke onset. Aspirin resistance, defined as high residual platelet reactivity (HRPR) on aspirin treatment, was measured using the VerifyNow assay and defined as an aspirin reaction unit >= 550. Initial stroke severity was assessed using the NIH Stroke Scale (NIHSS) score. Infarct volume was measured using DWI. Results: HRPR occurred in 86 patients (27.7%). The initial NIHSS score (median [interquartile range]) was higher in patients with HRPR than in the non-HRPR group (6 [3-15] vs 3 [1-8], p < 0.001). DWI infarct volumes were also larger in the HRPR group compared to the non-HRPR group (5.4 [0.8-43.2] vs 1.7 [0.4-10.3], p = 0.002). A multivariable median regression analysis showed that HRPR was significantly associated with an increase of 2.1 points on the NIHSS (95% confidence interval 0.8-4.0, p < 0.001) and an increase of 2.3 cm(3) in DWI infarct volume (95% confidence interval 0.4-3.9, p < 0.001). Conclusions: Aspirin resistance is associated with an increased risk of severe stroke and large infarct volume in patients taking aspirin before stroke onset. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ISCHEMIC-STROKE | - |
dc.subject | ANTIPLATELET USE | - |
dc.subject | INHIBITION | - |
dc.subject | PREVENTION | - |
dc.subject | MRI | - |
dc.title | Aspirin resistance is associated with increased stroke severity and infarct volume | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1212/WNL.0000000000002657 | - |
dc.identifier.scopusid | 2-s2.0-84978370403 | - |
dc.identifier.wosid | 000382000000013 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.86, no.19, pp.1808 - 1817 | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 86 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 1808 | - |
dc.citation.endPage | 1817 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | ANTIPLATELET USE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MRI | - |
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