Conversion pattern and predictive factor of mild cognitive impairment in elderly Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Sung-Mi | - |
dc.contributor.author | Song, Jihyun | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Jeon, Jae-Pil | - |
dc.date.accessioned | 2021-09-04T00:00:53Z | - |
dc.date.available | 2021-09-04T00:00:53Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0167-4943 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88712 | - |
dc.description.abstract | Objective: We aimed to understand conversion characteristics of mild cognitive impairment (MCI) in elderly Koreans. Methods: We analyzed clinical data of 760 individuals who participated in a two-year follow-up study. Neuropsychological assessments and clinical examination were conducted in the follow-ups. Logistic regression model was used to estimate predictive risk factors of MCI conversion. Result: The participants at baseline (n = 760) represented 462 cognitively normal individuals (60.8%), 286 individuals with MCI (37.6%), and 12 individuals with dementia (1.6%). Among the cognitively normal individuals (n = 462), 108 (23.4%) progressed to MCI during the two-year follow-up period, including 92 with amnestic mild cognitive impairment (aMCI; 19.9%) and 16 with non-amnestic mild cognitive impairment (non-aMCI; 3.5%). Interestingly, 3.7% of participants with aMCI converted to non-aMCI, while 45.5% of participants with non-aMCI converted to aMCI. Moreover, a higher proportion of non-aMCI (27.3%) reverted to a cognitively normal state, compared to aMCI participants (18.6%), indicating that non-amnestic cognitive impairment is more unstable than amnestic cognitive impairment, and probably converges toward aMCI. Additionally, we found that weight loss was associated with incident MCI and future MCI. Weight loss was negatively correlated with Clinical Dementia Rating (p = 0.005), and significantly associated with a higher risk of MCI conversion from a cognitively normal state (OR = 1.10, 95% CI: 1.00-1.21, p = 0.042). Conclusion: This study supports that non-amnestic MCI is prone to converge toward amnestic MCI, and the elderly people with weight loss are at risk for developing cognitive decline. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | ACCELERATED WEIGHT-LOSS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | DEMENTIA | - |
dc.subject | PROGRESSION | - |
dc.subject | PREVALENCE | - |
dc.subject | DIAGNOSIS | - |
dc.subject | COHORT | - |
dc.title | Conversion pattern and predictive factor of mild cognitive impairment in elderly Koreans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.identifier.doi | 10.1016/j.archger.2016.02.007 | - |
dc.identifier.scopusid | 2-s2.0-84959297465 | - |
dc.identifier.wosid | 000373341700021 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF GERONTOLOGY AND GERIATRICS, v.64, pp.146 - 150 | - |
dc.relation.isPartOf | ARCHIVES OF GERONTOLOGY AND GERIATRICS | - |
dc.citation.title | ARCHIVES OF GERONTOLOGY AND GERIATRICS | - |
dc.citation.volume | 64 | - |
dc.citation.startPage | 146 | - |
dc.citation.endPage | 150 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | ACCELERATED WEIGHT-LOSS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordAuthor | Mild cognitive impairment | - |
dc.subject.keywordAuthor | Predictive factor | - |
dc.subject.keywordAuthor | Weight loss | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.