Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation
DC Field | Value | Language |
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dc.contributor.author | Lee, Sam Jun | - |
dc.contributor.author | Kim, Tae Woon | - |
dc.contributor.author | Park, Hun Kyung | - |
dc.contributor.author | Yoon, Sangyun | - |
dc.contributor.author | You, Ann Hee | - |
dc.contributor.author | Moon, Eun Jin | - |
dc.contributor.author | Shin, Dong Hoon | - |
dc.contributor.author | Cho, Hanjin | - |
dc.date.accessioned | 2021-09-04T00:08:30Z | - |
dc.date.available | 2021-09-04T00:08:30Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 2093-4777 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88768 | - |
dc.description.abstract | Purpose: Stress during pregnancy is a risk factor for the development of anxiety-related disorders in offspring later in life. The effects of treadmill exercise on anxiety-like behaviors and hippocampal cell proliferation were investigated using rats exposed to prenatal stress. Methods: Exposure of pregnant rats to a hunting dog in an enclosed room was used to induce stress. Anxiety-like behaviors of offspring were evaluated using the elevated plus maze test. Immunohistochemistry for the detection of 5-bromo-2'deoxyuridine and doublecortin (DCX) in the hippocampal dentate gyrus and 5-hydroxytryptamine 1A receptors (5-HT1A) in the dorsal raphe was conducted. Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) levels in the hippocampus were evaluated by western blot analysis. Results: Offspring of maternal rats exposed to stress during pregnancy showed anxiety-like behaviors. Offspring also showed reduced expression of BDNF, TrkB, and DCX in the dentate gyrus, decreased cell proliferation in the hippocampus, and reduced 5-HT1A expression in the dorsal raphe. Postnatal treadmill exercise by offspring, but not maternal exercise during pregnancy, enhanced cell proliferation and expression of these proteins. Conclusions: Postnatal treadmill exercise ameliorated anxiety-like behaviors in offspring of stressed pregnant rats, and the alleviating effect of exercise on these behaviors is hypothesized to result from enhancement of cell proliferation through 5-HT1A activation in offspring rats. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CONTINENCE SOC | - |
dc.subject | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject | MATERNAL RATS | - |
dc.subject | DEPRESSION | - |
dc.subject | BDNF | - |
dc.subject | BEHAVIOR | - |
dc.subject | PLASTICITY | - |
dc.subject | SEROTONIN | - |
dc.subject | APOPTOSIS | - |
dc.subject | MEMORY | - |
dc.subject | ADULT | - |
dc.title | Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Hanjin | - |
dc.identifier.doi | 10.5213/inj.1632600.309 | - |
dc.identifier.scopusid | 2-s2.0-84973487350 | - |
dc.identifier.wosid | 000377002900009 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL NEUROUROLOGY JOURNAL, v.20, pp.S57 - S64 | - |
dc.relation.isPartOf | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.citation.title | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.citation.volume | 20 | - |
dc.citation.startPage | S57 | - |
dc.citation.endPage | S64 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002110803 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | MATERNAL RATS | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | ADULT | - |
dc.subject.keywordAuthor | Prenatal Exposure Delayed Effects | - |
dc.subject.keywordAuthor | Exercise Test | - |
dc.subject.keywordAuthor | Anxiety | - |
dc.subject.keywordAuthor | Cell Proliferation | - |
dc.subject.keywordAuthor | Serotonin | - |
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