Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Ha | - |
dc.contributor.author | Park, Jong-Jae | - |
dc.contributor.author | Lee, Beom Jae | - |
dc.contributor.author | Joo, Moon Kyung | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.contributor.author | Bak, Young-Tae | - |
dc.date.accessioned | 2021-09-04T00:13:02Z | - |
dc.date.available | 2021-09-04T00:13:02Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88801 | - |
dc.description.abstract | Background/Aims: Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. Methods: The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45, and SNU-1 were treated with various concentrations of astaxanthin. A cell viability test, cell cycle analysis, and immunoblotting were performed. Results: The viability of each cancer cell line was suppressed by astaxanthin in a dose-dependent manner with significantly decreased proliferation in KATO-III and SNU-1 cells. Astaxanthin increased the number of cells in the G0/G1 phase but reduced the proportion of S phase KATO-III and SNU-1 cells. Phosphorylated extracellular signal-regulated kinase (ERK) was decreased in an inverse dose-dependent correlation with astaxanthin concentration, and the expression of p27(kip-1) increased the KATO-III and SNU-1 cell lines in an astaxanthin dose-dependent manner. Conclusions: Astaxanthin inhibits proliferation by interrupting cell cycle progression in KATO-III and SNU-1 gastric cancer cells. This may be caused by the inhibition of the phosphorylation of ERK and the enhanced expression of p27(kip-1). | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.subject | HAEMATOCOCCUS ASTAXANTHIN | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | BETA-CAROTENE | - |
dc.subject | HUMAN HEALTH | - |
dc.subject | CHEMOPREVENTION | - |
dc.subject | APOPTOSIS | - |
dc.subject | MICE | - |
dc.subject | CARCINOGENESIS | - |
dc.subject | FIBROBLASTS | - |
dc.subject | PREVENTION | - |
dc.title | Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jong-Jae | - |
dc.contributor.affiliatedAuthor | Lee, Beom Jae | - |
dc.contributor.affiliatedAuthor | Joo, Moon Kyung | - |
dc.contributor.affiliatedAuthor | Chun, Hoon Jai | - |
dc.contributor.affiliatedAuthor | Lee, Sang Woo | - |
dc.contributor.affiliatedAuthor | Bak, Young-Tae | - |
dc.identifier.doi | 10.5009/gnl15208 | - |
dc.identifier.scopusid | 2-s2.0-84969165003 | - |
dc.identifier.wosid | 000375350000011 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.10, no.3, pp.369 - 374 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 369 | - |
dc.citation.endPage | 374 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002107699 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | HAEMATOCOCCUS ASTAXANTHIN | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BETA-CAROTENE | - |
dc.subject.keywordPlus | HUMAN HEALTH | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordAuthor | Astaxanthin | - |
dc.subject.keywordAuthor | Human gastric adenocarcinoma | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Extracellular signal-regulated kinase | - |
dc.subject.keywordAuthor | p27(kip-1) | - |
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