Three New Chalcones from the Aerial Parts of Angelica keiskei

Abstract

Three new chalcones, 3'-carboxymethyl-4,2'-dihydroxy-4'-methoxychalcone (1), (+/-)-4,2',4'-trihydroxy-3'-[(3-hydroxy-2,2-dimethyl-6-methylenecyclohexyl) methyl] chalcone (2), and 2 ''-hydroxyangelichalcone (3), were isolated from the aerial parts of Angelica keiskei (Umbelliferae) together with five known compounds, artocarmitin A (4), (+)-cis-(3'R, 4'R)-methylkhellactone (5), (-)-trans-(3'R, 4'S)-methylkhellactone (6), 3,4-dihydroxanthotoxin (7), and (Z)-p-coumaryl alcohol (8). The known compounds 4 - 8 were identified from A. keiskei for the first time. The structures of 1 -3 were elucidated by interpreting spectroscopic data including 1D- and 2D-NMR.