Amelioration of sepsis by TIE2 activation-induced vascular protection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sangyeul | - |
dc.contributor.author | Lee, Seung-Jun | - |
dc.contributor.author | Kim, Kyung Eun | - |
dc.contributor.author | Lee, Hyo Seon | - |
dc.contributor.author | Oh, Nuri | - |
dc.contributor.author | Park, Inwon | - |
dc.contributor.author | Ko, Eun | - |
dc.contributor.author | Oh, Seung Ja | - |
dc.contributor.author | Lee, Yoon-Sook | - |
dc.contributor.author | Kim, David | - |
dc.contributor.author | Lee, Seungjoo | - |
dc.contributor.author | Lee, Dae Hyun | - |
dc.contributor.author | Lee, Kwang-Hoon | - |
dc.contributor.author | Chae, Su Young | - |
dc.contributor.author | Lee, Jung-Hoon | - |
dc.contributor.author | Kim, Su-Jin | - |
dc.contributor.author | Kim, Hyung-Chan | - |
dc.contributor.author | Kim, Seokkyun | - |
dc.contributor.author | Kim, Sung Hyun | - |
dc.contributor.author | Kim, Chungho | - |
dc.contributor.author | Nakaoka, Yoshikazu | - |
dc.contributor.author | He, Yulong | - |
dc.contributor.author | Augustin, Hellmut G. | - |
dc.contributor.author | Hu, Junhao | - |
dc.contributor.author | Song, Paul H. | - |
dc.contributor.author | Kim, Yong-In | - |
dc.contributor.author | Kim, Pilhan | - |
dc.contributor.author | Kim, Injune | - |
dc.contributor.author | Koh, Gou Young | - |
dc.date.accessioned | 2021-09-04T00:27:16Z | - |
dc.date.available | 2021-09-04T00:27:16Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04-20 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88908 | - |
dc.description.abstract | Protection of endothelial integrity has been recognized as a frontline approach to alleviating sepsis progression, yet no effective agent for preserving endothelial integrity is available. Using an unusual anti-angiopoietin 2 (ANG2) antibody, ABTAA (ANG2-binding and TIE2-activating antibody), we show that activation of the endothelial receptor TIE2 protects the vasculature from septic damage and provides survival benefit in three sepsis mouse models. Upon binding to ANG2, ABTAA triggers clustering of ANG2, assembling an ABTAA/ANG2 complex that can subsequently bind and activate TIE2. Compared with a conventional ANG2-blocking antibody, ABTAA was highly effective in augmenting survival from sepsis by strengthening the endothelial glycocalyx, reducing cytokine storms, vascular leakage, and rarefaction, and mitigating organ damage. Together, our data advance the role of TIE2 activation in ameliorating sepsis progression and open a potential therapeutic avenue for sepsis to address the lack of sepsisspecific treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.subject | MULTIPLE-ORGAN DYSFUNCTION | - |
dc.subject | ENDOTHELIAL GLYCOCALYX | - |
dc.subject | LUNG INJURY | - |
dc.subject | AGONIST PEPTIDE | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | ANGIOPOIETIN-1 | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | MORTALITY | - |
dc.subject | COMP-ANG1 | - |
dc.subject | ANTIBODY | - |
dc.title | Amelioration of sepsis by TIE2 activation-induced vascular protection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chungho | - |
dc.identifier.doi | 10.1126/scitranslmed.aad9260 | - |
dc.identifier.scopusid | 2-s2.0-84964490181 | - |
dc.identifier.wosid | 000374412300004 | - |
dc.identifier.bibliographicCitation | SCIENCE TRANSLATIONAL MEDICINE, v.8, no.335 | - |
dc.relation.isPartOf | SCIENCE TRANSLATIONAL MEDICINE | - |
dc.citation.title | SCIENCE TRANSLATIONAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 335 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | MULTIPLE-ORGAN DYSFUNCTION | - |
dc.subject.keywordPlus | ENDOTHELIAL GLYCOCALYX | - |
dc.subject.keywordPlus | LUNG INJURY | - |
dc.subject.keywordPlus | AGONIST PEPTIDE | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
dc.subject.keywordPlus | ANTIBODY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.