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Preparation of aqueous alpha-lipoic acid dispersions with octenylsuccinylated high amylose starch

Authors
Li, Yi-XuanLim, Seung-Taik
Issue Date
20-4월-2016
Publisher
ELSEVIER SCI LTD
Keywords
Alpha-lipoic acid; High amylose starch; Octenylsuccinylated starch; Nano-dispersion; V-complex
Citation
CARBOHYDRATE POLYMERS, v.140, pp.253 - 259
Indexed
SCIE
SCOPUS
Journal Title
CARBOHYDRATE POLYMERS
Volume
140
Start Page
253
End Page
259
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/88909
DOI
10.1016/j.carbpol.2015.12.023
ISSN
0144-8617
Abstract
Aqueous dispersions prepared with OSA-modified high amylose starch were investigated in comparison with native high amylose starch and beta-cyclodextrin using alpha-lipoic acid as a model substance. Alpha-lipoic acid (ALA), a lipophilic antioxidant essential for energy metabolism in human, was dispersed in gelatinized starch solutions (1.0% w/v) at different temperatures (50-90 C) and times (3-12 h). High amylose starch modified with 3% OSA (dry starch base) was most favored in maximizing the dispersibility of ALA (84% recovery) under mild heating (70 degrees C for 3 h). The optimally prepared dispersion was milky white and contained particles with a narrow size distribution (200-300 nm). The precipitate isolated from the dispersion contained crystalline V -complexes of ALA and amylose while the supernatant contained free ALA accounting for 1/3 of total ALA, indicating OSA-modified high amylose starch stabilized ALA either by complexing with amylose or by retarding aggregation of ALA. (C) 2015 Elsevier Ltd. All rights reserved.
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