Sex-Specific Association between Longitudinal Changes in Adiposity, FTO rs9939609 Polymorphism, and Leukocyte Telomere Length
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Baik, Inkyung | - |
dc.date.accessioned | 2021-09-04T00:48:07Z | - |
dc.date.available | 2021-09-04T00:48:07Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04-02 | - |
dc.identifier.issn | 0731-5724 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88942 | - |
dc.description.abstract | Objective: A longitudinal study was conducted to examine sex-specific associations between changes in adiposity over a 10-year period, the FTO rs9939609 polymorphism, and leukocyte telomere length (LTL). Methods: A population-based cohort including 2128 middle-aged and older Korean men (n = 1087) and women (n = 1041) participated in a prospective study. Anthropometric measurements of weight, height, and waist and hip circumference were taken at baseline (from 2001 to 2003) and at the 10-year follow-up period (from 2011 to 2012). The FTO rs9939609 polymorphism was genotyped using DNA samples collected at baseline and LTL was assessed at the 10-year follow-up period. Multiple linear regression analysis was used with adjustments for age, baseline body mass index, and other potential confounders. Results: Presence of the FTO rs9939609 polymorphism risk allele was inversely associated with LTL (p < 0.01) in all participants, with a significant association seen only in women when the genders were modeled separately. Conversely, a significant inverse association between changes in waist circumference and LTL was found in men (p < 0.001) but not in women. No significant interaction between adiposity measures and the FTO polymorphism in association with LTL was identified for either sex. Conclusions: These data suggest that biological aging in men may be accelerated by increasing waist circumference, whereas in women, aging may be affected by genetic variations in FTO regardless of adiposity changes over time. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | PHYSICAL-ACTIVITY | - |
dc.subject | WAIST CIRCUMFERENCE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | AFRICAN-AMERICAN | - |
dc.subject | MORTALITY | - |
dc.subject | OBESITY | - |
dc.subject | VARIANT | - |
dc.subject | MEN | - |
dc.title | Sex-Specific Association between Longitudinal Changes in Adiposity, FTO rs9939609 Polymorphism, and Leukocyte Telomere Length | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.identifier.doi | 10.1080/07315724.2015.1005197 | - |
dc.identifier.scopusid | 2-s2.0-84939185871 | - |
dc.identifier.wosid | 000373287900006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, v.35, no.3, pp.245 - 254 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION | - |
dc.citation.title | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 254 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | WAIST CIRCUMFERENCE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | AFRICAN-AMERICAN | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordAuthor | biological aging | - |
dc.subject.keywordAuthor | longitudinal study | - |
dc.subject.keywordAuthor | leukocyte telomere length | - |
dc.subject.keywordAuthor | FTO polymorphism | - |
dc.subject.keywordAuthor | adiposity | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.