Heparin-immobilized hydroxyapatite nanoparticles as a lactoferrin delivery system for improving osteogenic differentiation of adipose-derived stem cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Lee, Deok-Won | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Jeon, Daniel I. | - |
dc.contributor.author | Rhee, Jin-Kyu | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2021-09-04T00:51:15Z | - |
dc.date.available | 2021-09-04T00:51:15Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88968 | - |
dc.description.abstract | The aim of this study is to fabricate lactoferrin (LF)-carrying hydroxyapatite nanoparticles (HAp NPs) to enhance osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs). HAp NPs were modified with heparin-dopamine (Hep-DOPA) (Hep-HAp) and further immobilized with LF (LF/Hep-HAp). Heparin immobilization on HAp NPs prevented aggregation of HAp NPs in aqueous solution and prolonged the release of LF from LF/Hep-HAp NPs. In vitro studies of rADSCs have demonstrated that LF-Hep/HAp NPs significantly increase alkaline phosphatase (ALP) activity, calcium deposition, and both mRNA expression of osteocalcin (OCN) and osteopontin (OPN) in comparison with HAp and Hep-HAp NPs. These results suggest that LF/Hep-HAp NPs can effectively induce osteogenic differentiation of rADSCs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.subject | ENHANCES BONE REPAIR | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | MICROSPHERES | - |
dc.subject | PROTEIN-2 | - |
dc.subject | RELEASE | - |
dc.subject | OSTEOBLASTS | - |
dc.subject | SURFACES | - |
dc.subject | COATINGS | - |
dc.subject | SCAFFOLD | - |
dc.subject | GROWTH | - |
dc.title | Heparin-immobilized hydroxyapatite nanoparticles as a lactoferrin delivery system for improving osteogenic differentiation of adipose-derived stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Yun, Young-Pil | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.identifier.doi | 10.1088/1748-6041/11/2/025004 | - |
dc.identifier.scopusid | 2-s2.0-84964523953 | - |
dc.identifier.wosid | 000375523400009 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, v.11, no.2 | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.citation.title | BIOMEDICAL MATERIALS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | ENHANCES BONE REPAIR | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | PROTEIN-2 | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | OSTEOBLASTS | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | COATINGS | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | hydroxyapatite nanoparticles | - |
dc.subject.keywordAuthor | heparin | - |
dc.subject.keywordAuthor | lactoferrin delivery | - |
dc.subject.keywordAuthor | adipose-derived stem cells | - |
dc.subject.keywordAuthor | osteogenic differentiation | - |
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