Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade
DC Field | Value | Language |
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dc.contributor.author | Park, Geun-Soo | - |
dc.contributor.author | Kim, Jeong-Keun | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-09-04T00:59:05Z | - |
dc.date.available | 2021-09-04T00:59:05Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89024 | - |
dc.description.abstract | Mulberry tree twigs (Ramulus mori) contain large amounts of oxyresveratrols and have traditionally been used as herbal medicines because of their anti-inflammatory properties. However, the signaling mechanism by which R. mori exerts its anti-inflammatory action remains to be elucidated. In this study, we observed that R. mori ethanol extracts (RME) exerted an inhibitory effect on the lipopolysaccharide (LPS)-induced production of the pro-inflammatory cytokine interleukin-6 (IL-6) in Raw264.7 macrophage cells. Additionally, RME inhibited IL-6 production by blocking the leukotriene B-4 receptor-2 (BLT2)-dependent-NADPH oxidase 1 (NOX1)-reactive oxygen species (ROS) cascade, leading to anti-inflammatory activity. Finally, RME suppressed the production of the BLT2 ligands LTB4 and 12(S)-HETE by inhibiting the p38 kinase-cytosolic phospholipase A(2)-5-/12-lipoxygenase cascade in LPS-stimulated Raw264.7 cells. Overall, our results suggest that RME inhibits the 'BLT2 ligand-BLT2'-linked autocrine inflammatory axis, and that this BLT2-linked cascade is one of the targets of the anti-inflammatory action of R. mori. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | INFLAMMATORY RESPONSES | - |
dc.subject | CANCER CELLS | - |
dc.subject | OXYRESVERATROL | - |
dc.subject | INTERLEUKIN-6 | - |
dc.subject | MACROPHAGES | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTOR | - |
dc.subject | SEPSIS | - |
dc.subject | BLT2 | - |
dc.subject | ALBA | - |
dc.title | Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.4.002 | - |
dc.identifier.scopusid | 2-s2.0-84966602640 | - |
dc.identifier.wosid | 000378131700008 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.49, no.4, pp.232 - 237 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 232 | - |
dc.citation.endPage | 237 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002102315 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | OXYRESVERATROL | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | BLT2 | - |
dc.subject.keywordPlus | ALBA | - |
dc.subject.keywordAuthor | BLT2 | - |
dc.subject.keywordAuthor | IL-6 | - |
dc.subject.keywordAuthor | Ramulus mori | - |
dc.subject.keywordAuthor | Raw264.7 cells | - |
dc.subject.keywordAuthor | ROS | - |
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