The Efficacy of Medical Treatment of Peyronie's Disease: Potassium Para-Aminobenzoate Monotherapy vs. Combination Therapy with Tamoxifen, L-Carnitine, and Phosphodiesterase Type 5 Inhibitor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Tae Yong | - |
dc.contributor.author | Jeong, Hyeong Guk | - |
dc.contributor.author | Park, Jong Jin | - |
dc.contributor.author | Chae, Ji Yun | - |
dc.contributor.author | Kim, Jong Wook | - |
dc.contributor.author | Oh, Mi Mi | - |
dc.contributor.author | Park, Hong Seok | - |
dc.contributor.author | Kim, Je Jong | - |
dc.contributor.author | Moon, Du Geon | - |
dc.date.accessioned | 2021-09-04T01:08:42Z | - |
dc.date.available | 2021-09-04T01:08:42Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 2287-4208 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89096 | - |
dc.description.abstract | Purpose: This study was designed to evaluate the efficacy of medical treatment of Peyronie's disease. Materials and Methods: A total of 109 patients with Peyronie's disease who had been treated from January 2011 to December 2014 were retrospectively reviewed in this study. Forty-four patients (Group 1) were treated with 12 mg of potassium para-aminobenzoate daily. Sixty-five patients (Group 2) were treated with combination therapy: tamoxifen (20 mg) and acetyl-L-carnitine (300 mg) twice daily in addition to a phosphodiesterase type 5 inhibitor. Ability to perform sexual intercourse, pain during erection, size of plaque, and penile curvature angle were assessed. Results: In Group 1, 30 of 44 patients (68.2%) discontinued treatment within 12 weeks, while 5 patients (7.7%) in Group 2 discontinued treatment. Pain during erection and plaque size were improved in both groups but showed no statistical difference due to the high dropout rate in Group 1. In both groups, penile curvature was improved, but demonstrated no statistical difference between the treatment groups. However, combination therapy demonstrated a better response rate in patients whose penile curvature angle was less than 30 degrees (44.4% vs. 79.1%, p=0.048). The rate of successful sexual intercourse was significantly higher in Group 2 (42.8% vs. 78.3%, p=0.034). The number of patients who underwent surgical correction despite medical treatment was significantly higher in Group 1 (35.7% vs. 13.3%, p=0.048). Conclusions: Early medical combination therapy in Peyronie's disease may present better results in patients whose curvature angle is less than 30 degrees. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC SEXUAL MEDICINE & ANDROLOGY | - |
dc.subject | PROPIONYL-L-CARNITINE | - |
dc.subject | ERECTILE DYSFUNCTION | - |
dc.subject | PDE5 INHIBITORS | - |
dc.subject | PLACEBO | - |
dc.subject | MANAGEMENT | - |
dc.subject | ETIOLOGY | - |
dc.subject | PLAQUE | - |
dc.title | The Efficacy of Medical Treatment of Peyronie's Disease: Potassium Para-Aminobenzoate Monotherapy vs. Combination Therapy with Tamoxifen, L-Carnitine, and Phosphodiesterase Type 5 Inhibitor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Mi Mi | - |
dc.contributor.affiliatedAuthor | Park, Hong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Je Jong | - |
dc.contributor.affiliatedAuthor | Moon, Du Geon | - |
dc.identifier.doi | 10.5534/wjmh.2016.34.1.40 | - |
dc.identifier.wosid | 000382849600006 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF MENS HEALTH, v.34, no.1, pp.40 - 46 | - |
dc.relation.isPartOf | WORLD JOURNAL OF MENS HEALTH | - |
dc.citation.title | WORLD JOURNAL OF MENS HEALTH | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 40 | - |
dc.citation.endPage | 46 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002100967 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Andrology | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | PROPIONYL-L-CARNITINE | - |
dc.subject.keywordPlus | ERECTILE DYSFUNCTION | - |
dc.subject.keywordPlus | PDE5 INHIBITORS | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ETIOLOGY | - |
dc.subject.keywordPlus | PLAQUE | - |
dc.subject.keywordAuthor | Drug therapy | - |
dc.subject.keywordAuthor | combination | - |
dc.subject.keywordAuthor | Penile induration | - |
dc.subject.keywordAuthor | 4-Aminobenzoic acid | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.