The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study
DC Field | Value | Language |
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dc.contributor.author | Moon, Jee Youn | - |
dc.contributor.author | Choi, Sang Sik | - |
dc.contributor.author | Lee, Shin Young | - |
dc.contributor.author | Lee, Mi Kyung | - |
dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Lee, So Hyun | - |
dc.date.accessioned | 2021-09-04T01:09:53Z | - |
dc.date.available | 2021-09-04T01:09:53Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 2005-9159 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89104 | - |
dc.description.abstract | Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanyl-sparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 mu g; Group B, fentanyl 500 mu g + nefopam 200 mg; and Group C, fentanyl 500 mu g + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN PAIN SOC | - |
dc.subject | PATIENT-CONTROLLED ANALGESIA | - |
dc.subject | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject | MULTIMODAL ANALGESIA | - |
dc.subject | ABDOMINAL-SURGERY | - |
dc.subject | MAJOR SURGERY | - |
dc.subject | PAIN | - |
dc.subject | MORPHINE | - |
dc.subject | EFFICACY | - |
dc.subject | SAFETY | - |
dc.subject | TRIALS | - |
dc.title | The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sang Sik | - |
dc.contributor.affiliatedAuthor | Lee, Mi Kyung | - |
dc.identifier.doi | 10.3344/kjp.2016.29.2.110 | - |
dc.identifier.scopusid | 2-s2.0-84962666731 | - |
dc.identifier.wosid | 000405330700007 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PAIN, v.29, no.2, pp.110 - 118 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PAIN | - |
dc.citation.title | KOREAN JOURNAL OF PAIN | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 110 | - |
dc.citation.endPage | 118 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002095261 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | PATIENT-CONTROLLED ANALGESIA | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | MULTIMODAL ANALGESIA | - |
dc.subject.keywordPlus | ABDOMINAL-SURGERY | - |
dc.subject.keywordPlus | MAJOR SURGERY | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordPlus | MORPHINE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordAuthor | Deep sedation | - |
dc.subject.keywordAuthor | Double blind study | - |
dc.subject.keywordAuthor | Hysterectomy | - |
dc.subject.keywordAuthor | Nefopam | - |
dc.subject.keywordAuthor | Opioids | - |
dc.subject.keywordAuthor | Pain measurement | - |
dc.subject.keywordAuthor | Patient-controlled analgesia | - |
dc.subject.keywordAuthor | Postoperative pain | - |
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