Investigation of the effect of erythrosine B on amyloid beta peptide using molecular modeling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Juho | - |
dc.contributor.author | Kwon, Inchan | - |
dc.contributor.author | Jang, Seung Soon | - |
dc.contributor.author | Cho, Art E. | - |
dc.date.accessioned | 2021-09-04T01:11:28Z | - |
dc.date.available | 2021-09-04T01:11:28Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1610-2940 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89115 | - |
dc.description.abstract | Neurotoxic plaques composed of 39 to 42 residue-long amyloid beta peptides (A beta s) are copiously present in the brains of patients with Alzheimer's disease (AD). Erythrosine B (ER), a xanthene food dye, inhibits the formation of A beta fibrils and A beta-associated cytotoxicity in vitro. Here, in an attempt to elucidate the inhibition mechanism, we performed molecular dynamics (MD) simulations to demonstrate the conformational change of A beta 40 induced by ER molecules in atomistic detail. During the simulation, the ER bound to the surfaces of both N-terminus and C-terminus regions of A beta 40. Our result shows that ER interacts with the aromatic side chains at the N-terminus region resulting in destabilization of the inter-chain stacking of A beta 40. Moreover, the stablility of the helical structures at the residues from 13 to 16 suggests that ER disturbs conformational transition of A beta 40. At the C-terminus region, the bound ER blocks water molecules and stabilizes the a-helical structure. Regardless of the number of ER molecules used, the interruption of the formation of the salt-bridge between aspartic acid 23 and lysine 28 occurred. To further validate our analysis, binding free energies of ER at each binding site were evaluated. The finding of stronger binding energy at the N-terminus region supports an inhibition mechanism induced by stacking interaction between ER and phenylalanine. These findings could aid present and future treatment studies for AD by clarifying the inhibition mechanism of ER on the conformational transition of A beta 40 at the molecular level. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | FORCE-FIELD | - |
dc.subject | SECONDARY STRUCTURE | - |
dc.subject | PRECURSOR PROTEIN | - |
dc.subject | FIBRIL FORMATION | - |
dc.subject | PI-STACKING | - |
dc.subject | CONGO RED | - |
dc.subject | DYNAMICS | - |
dc.subject | AGGREGATION | - |
dc.subject | SIMULATION | - |
dc.title | Investigation of the effect of erythrosine B on amyloid beta peptide using molecular modeling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Art E. | - |
dc.identifier.doi | 10.1007/s00894-016-2960-x | - |
dc.identifier.scopusid | 2-s2.0-85008490070 | - |
dc.identifier.wosid | 000373203900003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR MODELING, v.22, no.4 | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR MODELING | - |
dc.citation.title | JOURNAL OF MOLECULAR MODELING | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Computer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Computer Science, Interdisciplinary Applications | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | FORCE-FIELD | - |
dc.subject.keywordPlus | SECONDARY STRUCTURE | - |
dc.subject.keywordPlus | PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | FIBRIL FORMATION | - |
dc.subject.keywordPlus | PI-STACKING | - |
dc.subject.keywordPlus | CONGO RED | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | SIMULATION | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Amyloid beta | - |
dc.subject.keywordAuthor | Erythrosine B | - |
dc.subject.keywordAuthor | Molecular dynamics | - |
dc.subject.keywordAuthor | Pi-stacking | - |
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