Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study
DC Field | Value | Language |
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dc.contributor.author | Eom, Youngsub | - |
dc.contributor.author | Song, Jong Suk | - |
dc.contributor.author | Lee, Dong Yeol | - |
dc.contributor.author | Kim, Myo-Kyoung | - |
dc.contributor.author | Kang, Bo-Ram | - |
dc.contributor.author | Heo, Jeong-Hwa | - |
dc.contributor.author | Lee, Hyung Keun | - |
dc.contributor.author | Kim, Hyo Myung | - |
dc.date.accessioned | 2021-09-04T01:11:58Z | - |
dc.date.available | 2021-09-04T01:11:58Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1542-0124 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89119 | - |
dc.description.abstract | Purpose: To evaluate the effect of titanium dioxide (TiO2) nanoparticle exposure on the ocular surface. Methods: Eighty eyes of 40 rabbits were used. The TiO2-1D group (n = 20) received a single instillation of TiO2 in the right eye. The TiO2-4D group (n = 20) received a TiO2 instillation in the right eye once a day for four days. The 40 untreated left eyes were used as controls. Ocular surface staining (n = 5 for each group) was performed with rose bengal dye, tear secretion (n = 5) was measured using the phenol red thread test, lactic dehydrogenase (LDH) activity (n = 5) and MUC5AC levels (n = 5) were measured in tears, and the area of the conjunctival goblet cells (n = 5) was measured through impression cytology and scanning electron microscopy 24 hours after the last TiO2 instillation. Results: Ocular surface staining was increased but the tear secretion was not changed after TiO2 exposure. The TiO2-1D (1.39 OD) and TiO2-4D groups (0.58 OD) had higher median tear LDH activity than the control groups (0.57 OD and 0.29 OD, respectively). Although the median tear MUC5AC level in the TiO2-1D group (92.7 ng/ml) was higher than that of control 1 group (37.4 ng/ml), there was no significant difference in MUC5AC levels between the TiO2-4D and control 2 groups. Conjunctival goblet cell area decreased after TiO2 exposure. Conclusions: Exposure to TiO2 nanoparticles induced ocular surface damage. Although the tear MUC5AC level increased after a single exposure, it decreased to normal levels after repeated exposures. The area of conjunctival goblet cells decreased after TiO2 exposure. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | AIRBORNE PARTICULATE MATTER | - |
dc.subject | DRY EYE | - |
dc.subject | AIR-POLLUTION | - |
dc.subject | ALLERGIC CONJUNCTIVITIS | - |
dc.subject | IMPRESSION CYTOLOGY | - |
dc.subject | HEALTH | - |
dc.subject | PARTICLES | - |
dc.subject | MORTALITY | - |
dc.subject | TOXICITY | - |
dc.subject | CORNEAL | - |
dc.title | Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eom, Youngsub | - |
dc.contributor.affiliatedAuthor | Song, Jong Suk | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Myung | - |
dc.identifier.doi | 10.1016/j.jtos.2015.12.003 | - |
dc.identifier.scopusid | 2-s2.0-84963979972 | - |
dc.identifier.wosid | 000375222400015 | - |
dc.identifier.bibliographicCitation | OCULAR SURFACE, v.14, no.2, pp.224 - 232 | - |
dc.relation.isPartOf | OCULAR SURFACE | - |
dc.citation.title | OCULAR SURFACE | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 232 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | AIRBORNE PARTICULATE MATTER | - |
dc.subject.keywordPlus | DRY EYE | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | ALLERGIC CONJUNCTIVITIS | - |
dc.subject.keywordPlus | IMPRESSION CYTOLOGY | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | CORNEAL | - |
dc.subject.keywordAuthor | ocular surface | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | titanium dioxide | - |
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