Comparative study of BMP-2 alone and combined with VEGF carried by hydrogel for maxillary alveolar bone regeneration
DC Field | Value | Language |
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dc.contributor.author | Kim, Sook Kyoung | - |
dc.contributor.author | Cho, Tae Hyung | - |
dc.contributor.author | Han, Jeong Joon | - |
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Park, Yongdoo | - |
dc.contributor.author | Hwang, Soon Jung | - |
dc.date.accessioned | 2021-09-04T01:12:57Z | - |
dc.date.available | 2021-09-04T01:12:57Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89127 | - |
dc.description.abstract | The effect of vascular endothelial growth factor (VEGF) combined with bone morphogenetic protein-2 (BMP-2) for bone regeneration is still controversial as to whether or not VEGF has a synergistic or additive effect. This study attempted to evaluate the synergistic effect of VEGF and BMP-2 compared to BMP-2 alone for maxillary alveolar bone regeneration using collagen sponge/hydrogel complex sheets in a canine model. After mixing BMP-2 and VEGF with a hyaluronic acid-based hydrogel (HAH), the collagen sponge/hydrogel complex was transplanted into maxillary alveolar bone defects (n=14) after the extraction of canine upper first molars on both sides. Bone regeneration was evaluated in three groups (control group without growth factors, experimental groups I and II with BMP-2 alone and BMP-2 and VEGF, respectively) using micro-computed tomography and histological staining. The total amount of new bone formations and bone mineral density were significantly higher in the group with BMP-2 only and the group with BMP-2 combined with VEGF than it in the control group. The area with positive staining of von Willebrand factor bone defect was significantly greater in the group with BMP-2 only and with dual growth factors than the control. BMP-2 released from the HAH promoted new bone formation. However, the combination of BMP-2 and VEGF did not show a synergistic or additive effect on bone regeneration at canine maxillary alveolar bone defects. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | SINUS FLOOR AUGMENTATION | - |
dc.subject | SIZE DEFECT MODEL | - |
dc.subject | MORPHOGENETIC PROTEIN-2 | - |
dc.subject | OSTEOBLAST DIFFERENTIATION | - |
dc.subject | COLLAGEN SPONGE | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | DUAL DELIVERY | - |
dc.subject | ANGIOGENESIS | - |
dc.title | Comparative study of BMP-2 alone and combined with VEGF carried by hydrogel for maxillary alveolar bone regeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongdoo | - |
dc.identifier.doi | 10.1007/s13770-015-0046-y | - |
dc.identifier.scopusid | 2-s2.0-84962424471 | - |
dc.identifier.wosid | 000373639000007 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.13, no.2, pp.171 - 181 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 181 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002096334 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | SINUS FLOOR AUGMENTATION | - |
dc.subject.keywordPlus | SIZE DEFECT MODEL | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | OSTEOBLAST DIFFERENTIATION | - |
dc.subject.keywordPlus | COLLAGEN SPONGE | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | DUAL DELIVERY | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordAuthor | Maxillary alveolar bone defect | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
dc.subject.keywordAuthor | Synergistic effect | - |
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