Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-kappa B Inhibitors and Cytotoxic Agents
DC Field | Value | Language |
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dc.contributor.author | Jo, Hyeju | - |
dc.contributor.author | Choi, Minho | - |
dc.contributor.author | Kumar, Areyalli Sateesh | - |
dc.contributor.author | Jung, Yeongeun | - |
dc.contributor.author | Kim, Sangeun | - |
dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Kang, Jong-Soon | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Han, Sang-bae | - |
dc.contributor.author | Jung, Jae-Kyung | - |
dc.contributor.author | Cho, Jungsook | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Kwak, Jae-Hwan | - |
dc.contributor.author | Lee, Heesoon | - |
dc.date.accessioned | 2021-09-04T01:14:30Z | - |
dc.date.available | 2021-09-04T01:14:30Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1948-5875 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89139 | - |
dc.description.abstract | 1,2,3,4-Tetrahydroquinolines have been identified as the most potent inhibitors of LPS-induced NF-kappa B transcriptional activity. To discover new molecules of this class with excellent activities, we designed and synthesized a series of novel derivatives of 1,2,3,4-tetrahydroquinolines (4a-g, 5a-h, 6a-h, and 7a-h) and bioevaluated their in vitro activity against human cancer cell lines (NCI-H23, ACHN, MDA-MB-231, PC-3, NUGC-3, and HCT 15). Among all synthesized scaffolds, 6g exhibited the most potent inhibition (53 times that of a reference compound) of LPS-induced NF-kappa B transcriptional activity and the most potent cytotoxicity against all evaluated human cancer cell lines. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | DERIVATIVES | - |
dc.subject | ACTIVATION | - |
dc.subject | PROGRESS | - |
dc.subject | DESIGN | - |
dc.subject | MODEL | - |
dc.title | Development of Novel 1,2,3,4-Tetrahydroquinoline Scaffolds as Potent NF-kappa B Inhibitors and Cytotoxic Agents | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.identifier.doi | 10.1021/acsmedchemlett.6b00004 | - |
dc.identifier.scopusid | 2-s2.0-84965081967 | - |
dc.identifier.wosid | 000374436700010 | - |
dc.identifier.bibliographicCitation | ACS MEDICINAL CHEMISTRY LETTERS, v.7, no.4, pp.385 - 390 | - |
dc.relation.isPartOf | ACS MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | ACS MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 385 | - |
dc.citation.endPage | 390 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROGRESS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | 1,2,3,4-Tetrahydroquinolines | - |
dc.subject.keywordAuthor | NF-kappa B inactivation | - |
dc.subject.keywordAuthor | in vitro cytotoxicity | - |
dc.subject.keywordAuthor | human cancer cell lines | - |
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