Identification of potential biomarkers for xylene exposure by microarray analyses of gene expression and methylation
- Authors
- Kim, Seol Young; Hong, Ji Young; Yu, So-Yeon; Kim, Gi Won; Ahn, Jeong Jin; Kim, Youngjoo; Son, Sang Wook; Park, Jong-Tae; Hwang, Seung Yong
- Issue Date
- 31-3월-2016
- Publisher
- KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
- Keywords
- Xylene; Microarray; Gene expression; Methylation; Biomarker
- Citation
- MOLECULAR & CELLULAR TOXICOLOGY, v.12, no.1, pp.15 - 20
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULAR & CELLULAR TOXICOLOGY
- Volume
- 12
- Number
- 1
- Start Page
- 15
- End Page
- 20
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89180
- DOI
- 10.1007/s13273-016-0003-4
- ISSN
- 1738-642X
- Abstract
- Xylene is volatile organic compound that has been reported to increase the incidence of cancer and various diseases related to the immune system, cardiovascular systems, respiratory and reproductive organs. However, there are currently few biomarkers in human cases. Using microarray, we analysed 10 participants for the xylene-exposure group and 10 controls that were not exposed to xylene. The two groups were compared in terms of expression levels and methylation patterns. We identified 6 genes that were down-regulated and hyper-methylated, and 132 that were up-regulated and hypo-methylated in the xylene-exposure group compared to control. We sorted out and 28 biomarker candidates were chosen using DAVID. And then, we used IPA to select the significant potential biomarkers in them. We used network analysis and selected 6 significant genes, and these 6 genes showed altered expression and methylation in xylene-exposure group, suggesting that they are suitable potential biomarkers for xylene exposure.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.