Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [F-18]FP-CIT PET Imaging Pilot Study
DC Field | Value | Language |
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dc.contributor.author | Park, Eunkyung | - |
dc.contributor.author | Hwang, Yu Mi | - |
dc.contributor.author | Chu, Min Kyung | - |
dc.contributor.author | Jung, Ki-Young | - |
dc.date.accessioned | 2021-09-04T01:58:37Z | - |
dc.date.available | 2021-09-04T01:58:37Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89267 | - |
dc.description.abstract | Purpose Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2 eta-carbomethoxy-3 beta-(4-iodophenyl) nortropane ([F-18]FP-CIT) positron emission tomography (PET). Methods Brain [F-18]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BPND) of [F-18]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters. Results BPND at the brainstem was significantly higher in adult migraineurs (n=6, 1.15 +/- 0.17) than healthy subjects (0.95 +/- 0.14) (p=0.04). Healthy subjects demonstrated negative correlation between brainstem BPND and age (r=-0.64, p=0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BPND (r=0.66, p=0.02), when age and duration of illness were corrected. Conclusions Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [F-18]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | DOPAMINE TRANSPORTERS | - |
dc.subject | BINDING | - |
dc.subject | SPECT | - |
dc.title | Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [F-18]FP-CIT PET Imaging Pilot Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Yu Mi | - |
dc.identifier.doi | 10.1007/s13139-015-0373-x | - |
dc.identifier.scopusid | 2-s2.0-84960116017 | - |
dc.identifier.wosid | 000386255800010 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.50, no.1, pp.70 - 75 | - |
dc.relation.isPartOf | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.title | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 75 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002089790 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | DOPAMINE TRANSPORTERS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SPECT | - |
dc.subject.keywordAuthor | Migraine | - |
dc.subject.keywordAuthor | Serotonin transporter | - |
dc.subject.keywordAuthor | [F-18]FP-CIT | - |
dc.subject.keywordAuthor | Positron emission tomography | - |
dc.subject.keywordAuthor | Brainstem | - |
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