Semi-Quantitative Analysis of Post-Transarterial Radioembolization Y-90 Microsphere Positron Emission Tomography Combined with Computed Tomography (PET/CT) Images in Advanced Liver Malignancy: Comparison With Tc-99m Macroaggregated Albumin (MAA) Single Photon Emission Computed Tomography (SPECT)
DC Field | Value | Language |
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dc.contributor.author | Rhee, Seunghong | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Cho, Jaehyuk | - |
dc.contributor.author | Park, Jukyung | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Park, Soyeon | - |
dc.contributor.author | Lee, Eunsub | - |
dc.contributor.author | Kim, Yun Hwan | - |
dc.contributor.author | Choe, Jae-Gol | - |
dc.date.accessioned | 2021-09-04T02:08:18Z | - |
dc.date.available | 2021-09-04T02:08:18Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89344 | - |
dc.description.abstract | Objectives The purpose of this study is to evaluate the correlation between pretreatment planning technetium-99m (Tc-99m) macroaggregated albumin (MAA) SPECT images and posttreatment transarterial radioembolization (TARE) yttirum-90 (Y-90) PET/CT images by comparing the ratios of tumor-to-normal liver counts. Methods Fifty-two patients with advanced hepatic malignancy who underwent Y-90 microsphere radioembolization from January 2010 to December 2012 were retrospectively reviewed. Patients had undergone Tc-99m MAA intraarterial injection SPECT for a pretreatment evaluation of microsphere distribution and therapy planning. After the administration of Y-90 microspheres, the patients underwent posttreatment Y-90 PET/CT within 24 h. For semiquantitative analysis, the tumor-to-normal uptake ratios in Y-90 PET/CT (TNR-yp) and Tc-99m MAA SPECT (TNR-ms) as well as the tumor volumes measured in angiographic CT were obtained and analyzed. The relationship of TNR-yp and TNR-ms was evaluated by Spearman's rank correlation and Wilcoxon's matched pairs test. Results In a total of 79 lesions of 52 patients, the distribution of microspheres was well demonstrated in both the SPECT and PET/CT images. A good correlation was observed of between TNR-ms and TNR-yp (rho value=0.648, p<0.001). The TNR-yp (median 2.78, interquartile range 2.43) tend to show significantly higher values than TNR-ms (median 2.49, interquartile range of 1.55) (p=0.012). The TNR-yp showed weak correlation with tumor volume (rho=0.230, p=0.041). Conclusions The Tc-99m MAA SPECT showed a good correlation with Y-90 PET/CT in TNR values, suggesting that Tc-99m MAA can be used as an adequate pretreatment evaluation method. However, the Tc-99m MAA SPECT image consistently shows lower TNR values compared to Y-90 PET/CT, which means the possibility of underestimation of tumorous uptake in the partition dosimetry model using Tc-99m MAA SPECT. Considering that Tc-99m MAA is the only clinically available surrogate marker for distribution of microsphere, we recommend measurement of tumorous uptake using Y-90 PET/CT should be included routinely in the posttherapeutic evaluation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | INTERNAL RADIATION-THERAPY | - |
dc.subject | HEPATOCELLULAR-CARCINOMA PATIENTS | - |
dc.subject | PORTAL-VEIN THROMBOSIS | - |
dc.subject | RESIN MICROSPHERES | - |
dc.subject | INTRAOPERATIVE DOSIMETRY | - |
dc.subject | PARTITION MODEL | - |
dc.subject | HEPATIC CANCER | - |
dc.subject | UPTAKE RATIO | - |
dc.subject | TUMOR | - |
dc.subject | CHEMOTHERAPY | - |
dc.title | Semi-Quantitative Analysis of Post-Transarterial Radioembolization Y-90 Microsphere Positron Emission Tomography Combined with Computed Tomography (PET/CT) Images in Advanced Liver Malignancy: Comparison With Tc-99m Macroaggregated Albumin (MAA) Single Photon Emission Computed Tomography (SPECT) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Eo, Jae Seon | - |
dc.contributor.affiliatedAuthor | Choe, Jae-Gol | - |
dc.identifier.doi | 10.1007/s13139-015-0366-9 | - |
dc.identifier.scopusid | 2-s2.0-84959533165 | - |
dc.identifier.wosid | 000386255800009 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.50, no.1, pp.63 - 69 | - |
dc.relation.isPartOf | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.title | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 69 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002089788 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | INTERNAL RADIATION-THERAPY | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA PATIENTS | - |
dc.subject.keywordPlus | PORTAL-VEIN THROMBOSIS | - |
dc.subject.keywordPlus | RESIN MICROSPHERES | - |
dc.subject.keywordPlus | INTRAOPERATIVE DOSIMETRY | - |
dc.subject.keywordPlus | PARTITION MODEL | - |
dc.subject.keywordPlus | HEPATIC CANCER | - |
dc.subject.keywordPlus | UPTAKE RATIO | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | Tc-99m-MAA | - |
dc.subject.keywordAuthor | Radioembolization | - |
dc.subject.keywordAuthor | Y-90 | - |
dc.subject.keywordAuthor | Microsphere | - |
dc.subject.keywordAuthor | Liver malignancy | - |
dc.subject.keywordAuthor | PET scan | - |
dc.subject.keywordAuthor | Single-photon emission computerized tomography | - |
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