Correlation between Semi-Quantitative F-18-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Park, Soyeon | - |
dc.contributor.author | Lee, Eunsub | - |
dc.contributor.author | Rhee, Seunghong | - |
dc.contributor.author | Cho, Jaehyuk | - |
dc.contributor.author | Choi, Sunju | - |
dc.contributor.author | Lee, Sinae | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Pahk, Kisoo | - |
dc.contributor.author | Choe, Jae Gol | - |
dc.contributor.author | Kim, Sungeun | - |
dc.date.accessioned | 2021-09-04T02:08:48Z | - |
dc.date.available | 2021-09-04T02:08:48Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89348 | - |
dc.description.abstract | Purpose The aimof this study was to evaluate the relationship between semiquantitative parameters on F-18-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent F-18-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on F-18-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p=0.526 and 0.729, respectively). Conclusion In conclusion, the volume-based parameters of F-18-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by F-18-FDG PET/CT might be a simple, non-invasive, and useful method to determine the proliferative potential of cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | MALIGNANT PLEURAL MESOTHELIOMA | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | NEUROENDOCRINE TUMORS | - |
dc.subject | PROLIFERATION INDEX | - |
dc.subject | BREAST-CANCER | - |
dc.subject | FDG UPTAKE | - |
dc.subject | SURVIVAL | - |
dc.subject | PREDICTS | - |
dc.subject | VOLUME | - |
dc.subject | CHEMOTHERAPY | - |
dc.title | Correlation between Semi-Quantitative F-18-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eo, Jae Seon | - |
dc.contributor.affiliatedAuthor | Choe, Jae Gol | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.identifier.doi | 10.1007/s13139-015-0363-z | - |
dc.identifier.scopusid | 2-s2.0-84959497771 | - |
dc.identifier.wosid | 000386255800004 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.50, no.1, pp.24 - 30 | - |
dc.relation.isPartOf | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.title | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 30 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002089769 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | MALIGNANT PLEURAL MESOTHELIOMA | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | NEUROENDOCRINE TUMORS | - |
dc.subject.keywordPlus | PROLIFERATION INDEX | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | FDG UPTAKE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PREDICTS | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | Small-cell lung carcinoma | - |
dc.subject.keywordAuthor | F-18-FDG PET/CT | - |
dc.subject.keywordAuthor | Metabolic tumor volume | - |
dc.subject.keywordAuthor | Ki-67 | - |
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