Prognostic Value of the Sum of Metabolic Tumor Volume of Primary Tumor and Lymph Nodes Using F-18-FDG PET/CT in Patients With Cervical Cancer
DC Field | Value | Language |
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dc.contributor.author | Hong, Jin Hwa | - |
dc.contributor.author | Min, Kyung Jin | - |
dc.contributor.author | Lee, Jae Kwan | - |
dc.contributor.author | So, Kyeong A. | - |
dc.contributor.author | Jung, Un Suk | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.date.accessioned | 2021-09-04T02:19:00Z | - |
dc.date.available | 2021-09-04T02:19:00Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89426 | - |
dc.description.abstract | This is an observational study to determine the most relevant parameter of F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for predicting recurrence in cervical cancer. Fifty-six patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-IVA cervical cancer who underwent pretreatment (18) F-FDG PET/CT were enrolled. PET parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of both primary tumor and pelvic and/or para-aortic lymph nodes were analyzed. SUVmax-S was defined as the sum of the SUVmax of primary tumor and the higher SUVmax of either pelvic or para-aortic lymph nodes. MTV-S was defined as the sum of the MTV of primary tumor and pelvic and para-aortic lymph nodes. TLG-S was calculated in the same way as MTV-S. We evaluated the relationship between these PET parameters and recurrence-free survival (RFS). Univariate analysis revealed that higher FIGO stage (hazard ratio [HR] = 5.61, 95% confidence interval [CI]: 1.68-18.68, P = 0.005), lymph node metastasis (HR = 3.42, 95% CI: 1.08-10.84, P = 0.037), MTV of primary tumor >47.81 cm(3) (HR = 6.20, 95% CI: 1.35-28.48, P = 0.019), TLG of primary tumor >215.02 (HR = 11.82, 95% CI: 1.52-91.96, P = 0.018), MTV-S >59.01 cm(3) (HR = 8.24, 95% CI: 1.80-37.77, P = 0.007), and TLG-S >224.15 (HR = 13.09, 95% CI: 1.68-101.89, P = 0.014) were associated with RFS. In multivariate analysis, FIGO stage (HR = 4.87, 95% CI: 1.38-17.18, P = 0.014) and MTV-S >59.01 cm(3) (HR = 7.37, 95% CI: 1.54-35.16, P = 0.012) were determined to be independent predictive factors for RFS. Our preliminary results reveal that MTV-S is an independent prognostic factor for RFS in patients with cervical cancer treated by definitive chemoradiotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | STANDARDIZED UPTAKE VALUE | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | METASTASES | - |
dc.subject | CARCINOMA | - |
dc.subject | FLUORODEOXYGLUCOSE | - |
dc.subject | RECURRENCE | - |
dc.subject | THERAPY | - |
dc.title | Prognostic Value of the Sum of Metabolic Tumor Volume of Primary Tumor and Lymph Nodes Using F-18-FDG PET/CT in Patients With Cervical Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jin Hwa | - |
dc.contributor.affiliatedAuthor | Min, Kyung Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jae Kwan | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Eo, Jae Seon | - |
dc.identifier.doi | 10.1097/MD.0000000000002992 | - |
dc.identifier.scopusid | 2-s2.0-84962509118 | - |
dc.identifier.wosid | 000375208900057 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.95, no.9 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 95 | - |
dc.citation.number | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | STANDARDIZED UPTAKE VALUE | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | METASTASES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | FLUORODEOXYGLUCOSE | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | THERAPY | - |
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