Risk Assessment of Hepatocellular Carcinoma Using Transient Elastography Vs. Liver Biopsy in Chronic Hepatitis B Patients Receiving Antiviral Therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Mi Na | - |
dc.contributor.author | Kim, Seung Up | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Han, Kwang-Hyub | - |
dc.contributor.author | Kim, Young Seok | - |
dc.date.accessioned | 2021-09-04T02:19:55Z | - |
dc.date.available | 2021-09-04T02:19:55Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89433 | - |
dc.description.abstract | Liver stiffness (LS) assessed using transient elastography (TE) can assess the risk of developing hepatocellular carcinoma (HCC). We evaluated whether TE, when compared with histological data as a reference standard, can predict the risk of HCC development in chronic hepatitis B (CHB) patients starting antiviral therapy. Observational cohort database of 381 patients with CHB who underwent liver biopsy (LB) and TE were reviewed. All patients underwent surveillance for HCC development using ultrasonography and alpha-fetoprotein. During the median follow-up period of 48.1 (interquartile range 30.3-69.3) months, HCC developed in 34 (8.9%) patients. In patients with HCC development, age, proportion of diabetes mellitus, histological fibrosis stage, and LS value were significantly higher than those in patients without (all P <0.05). The cumulative incidence rates of HCC increased significantly in association with elevated LS value in 3 stratified groups (LS value <8, 8-13, and >13 kPa; log-rank test, P <0.001), and with higher histological fibrosis stage in 3 stratified groups (F0-2, F3, and F4; log-rank test, P <0.001). On multivariate analysis, along with age, LS value was an independent predictor of HCC development (hazard ratio 1.041, P <0.001), whereas histological staging was not (P>0.05). TE predicted HCC development independently in patients with CHB starting antiviral therapy. However, further investigation is needed to determine whether the current surveillance strategy can be optimized based on the LS value at the time of starting antiviral therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | CHRONIC VIRAL-HEPATITIS | - |
dc.subject | NATURAL-HISTORY | - |
dc.subject | NONINVASIVE PREDICTION | - |
dc.subject | CLINICAL-APPLICATION | - |
dc.subject | CIRRHOSIS | - |
dc.subject | EVENTS | - |
dc.subject | FIBROSIS | - |
dc.subject | UPDATE | - |
dc.title | Risk Assessment of Hepatocellular Carcinoma Using Transient Elastography Vs. Liver Biopsy in Chronic Hepatitis B Patients Receiving Antiviral Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Yeon Seok | - |
dc.contributor.affiliatedAuthor | Um, Soon Ho | - |
dc.identifier.doi | 10.1097/MD.0000000000002985 | - |
dc.identifier.scopusid | 2-s2.0-84962166031 | - |
dc.identifier.wosid | 000375256400010 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.95, no.12 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 95 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CHRONIC VIRAL-HEPATITIS | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | NONINVASIVE PREDICTION | - |
dc.subject.keywordPlus | CLINICAL-APPLICATION | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | UPDATE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.