Acute bulbar palsy as a variant of Guillain-Barre syndrome
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong Kuk | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.contributor.author | Shin, Ha Young | - |
dc.contributor.author | Shin, Kyong Jin | - |
dc.contributor.author | Nam, Tai-Seung | - |
dc.contributor.author | Oh, Jeeyoung | - |
dc.contributor.author | Suh, Bum Chun | - |
dc.contributor.author | Yoon, Byeol-A | - |
dc.contributor.author | Park, Hwan Tae | - |
dc.contributor.author | Huh, So-Young | - |
dc.contributor.author | Oh, Seong-Il | - |
dc.contributor.author | Bae, Jong Seok | - |
dc.date.accessioned | 2021-09-04T02:33:12Z | - |
dc.date.available | 2021-09-04T02:33:12Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02-23 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89481 | - |
dc.description.abstract | Objective: To categorize a syndrome manifesting as prominent acute bulbar palsy (ABP) without limb motor weakness as a variant form of Guillain-Barre syndrome (GBS) and differentiate it from Miller Fisher syndrome (MFS) and pharyngeal-cervical-brachial (PCB) variants. Methods: We analyzed cases of ABP without limb motor weakness based on a dataset containing clinical information and the results of antiganglioside antibodies assays for acute immune-mediated neuropathies. Results: Eleven cases with an age at onset ranging from 18 to 65 years (mean 33.8 years) were identified as ABP-plus syndrome. All of the enrolled cases manifested with ABP as the predominant symptom, and with no limb weakness. The following features accompanied ABP in order of decreasing frequency: ophthalmoplegia (n = 9, 82%), ataxia (n = 9, 82%), and facial palsy (n = 6, 55%). An enzyme-linked immunosorbent assay study disclosed that immunoglobulin G (IgG) anti-GT1a antibodies were the most frequent (n = 11), followed by IgG anti-GQ1b antibodies (n = 6). Conclusions: We propose that ABP-plus syndrome without neck or limb weakness is a variant of GBS that is distinct from the MFS and PCB variants. The presence of IgG anti-GT1a antibodies can explain the relationships between the distinct clinical characteristics and the underlying pathomechanisms. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | CERVICAL-BRACHIAL WEAKNESS | - |
dc.subject | ANTIGANGLIOSIDE ANTIBODIES | - |
dc.subject | IGG ANTIBODY | - |
dc.subject | POLYNEURITIS CRANIALIS | - |
dc.subject | OROPHARYNGEAL PALSY | - |
dc.subject | GANGLIOSIDES | - |
dc.subject | COMPLEXES | - |
dc.title | Acute bulbar palsy as a variant of Guillain-Barre syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Jo | - |
dc.identifier.doi | 10.1212/WNL.0000000000002256 | - |
dc.identifier.scopusid | 2-s2.0-84959215798 | - |
dc.identifier.wosid | 000371498400008 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.86, no.8, pp.742 - 747 | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 86 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 742 | - |
dc.citation.endPage | 747 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | CERVICAL-BRACHIAL WEAKNESS | - |
dc.subject.keywordPlus | ANTIGANGLIOSIDE ANTIBODIES | - |
dc.subject.keywordPlus | IGG ANTIBODY | - |
dc.subject.keywordPlus | POLYNEURITIS CRANIALIS | - |
dc.subject.keywordPlus | OROPHARYNGEAL PALSY | - |
dc.subject.keywordPlus | GANGLIOSIDES | - |
dc.subject.keywordPlus | COMPLEXES | - |
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