Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Byeongha | - |
dc.contributor.author | Hong, Jin Hee | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Choe, Han Kyoung | - |
dc.contributor.author | Kim, Kyungjin | - |
dc.contributor.author | Lee, Kyoung J. | - |
dc.date.accessioned | 2021-09-04T02:43:57Z | - |
dc.date.available | 2021-09-04T02:43:57Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02-19 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89493 | - |
dc.description.abstract | The suprachiasmatic nucleus (SCN) is a group of cells that functions as a biological master clock. In different SCN cells, oscillations of biochemical markers such as the expression-level of clock genes, are not synchronized but instead form slow circadian phase waves propagating over the whole cell population spatio-temporal struc- ture is a fixed property set by the anatomy of a given SCN. Here, we show that this is not the case in early postnatal SCN. Earlier studies presumed that their Based on bioluminescence imaging experiments with Per2-Luciferase mice SCN cultures which guided computer simulations of a realistic model of the SCN, we demonstrate that the wave is not unique but can be in various modes including phase-coherent oscillation, crescent-shaped wave, and most notably, a rotating pinwheel wave that conceptually resembles a wall clock with a rotating hand. Furthermore, mode transitions can be induced by a pulse of 38.5 degrees C temperature perturbation. Importantly, the waves support a significantly different period, suggesting that neither a spatially-fixed phase ordering nor a specialized pacemaker having a fixed period exist in these studied SCNs. These results lead to new important questions of what the observed multi-stability means for the proper function of an SCN and its arrhythmia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CELLULAR CLOCKS | - |
dc.subject | NEURONS | - |
dc.subject | NETWORK | - |
dc.subject | TEMPERATURE | - |
dc.subject | RHYTHMS | - |
dc.subject | SCN | - |
dc.subject | OSCILLATOR | - |
dc.subject | SYNCHRONY | - |
dc.subject | ORGANIZATION | - |
dc.subject | SENSITIVITY | - |
dc.title | Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyoung J. | - |
dc.identifier.doi | 10.1038/srep21463 | - |
dc.identifier.scopusid | 2-s2.0-84959019123 | - |
dc.identifier.wosid | 000370480400002 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CELLULAR CLOCKS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | RHYTHMS | - |
dc.subject.keywordPlus | SCN | - |
dc.subject.keywordPlus | OSCILLATOR | - |
dc.subject.keywordPlus | SYNCHRONY | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.