Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers
DC Field | Value | Language |
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dc.contributor.author | Singh, Sarbjit | - |
dc.contributor.author | Gajulapati, Veeraswamy | - |
dc.contributor.author | Gajulapati, Kondaji | - |
dc.contributor.author | Goo, Ja-Il | - |
dc.contributor.author | Park, Yeon-Hwa | - |
dc.contributor.author | Jung, Hwa Young | - |
dc.contributor.author | Lee, Sung Yoon | - |
dc.contributor.author | Choi, Jung Ho | - |
dc.contributor.author | Kim, Young Kook | - |
dc.contributor.author | Lee, Kyeong | - |
dc.contributor.author | Heo, Tae-Hwe | - |
dc.contributor.author | Choi, Yongseok | - |
dc.date.accessioned | 2021-09-04T02:52:46Z | - |
dc.date.available | 2021-09-04T02:52:46Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89517 | - |
dc.description.abstract | A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 mu M which was much better than (+)-Madindoline A (IC50 = 21 mu M), a known inhibitor of IL-6. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | ACUTE-PANCREATITIS | - |
dc.subject | GLYCOPROTEIN 130 | - |
dc.subject | MADINDOLINE-A | - |
dc.subject | INTERLEUKIN-6 | - |
dc.subject | INHIBITION | - |
dc.subject | ANTAGONIST | - |
dc.subject | GP130 | - |
dc.title | Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.identifier.doi | 10.1016/j.bmcl.2016.01.016 | - |
dc.identifier.scopusid | 2-s2.0-84958103583 | - |
dc.identifier.wosid | 000369377700037 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.4, pp.1282 - 1286 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1282 | - |
dc.citation.endPage | 1286 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ACUTE-PANCREATITIS | - |
dc.subject.keywordPlus | GLYCOPROTEIN 130 | - |
dc.subject.keywordPlus | MADINDOLINE-A | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | GP130 | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | IL-6 antagonists | - |
dc.subject.keywordAuthor | IL-6 signaling inhibitor | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | gp130 | - |
dc.subject.keywordAuthor | Oxazolidinone | - |
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