Predictive Role of Functional Visceral Fat Activity Assessed by Preoperative F-18 FDG PET/CT for Regional Lymph Node or Distant Metastasis in Patients with Colorectal Cancer
DC Field | Value | Language |
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dc.contributor.author | Pahk, Kisoo | - |
dc.contributor.author | Rhee, Seunghong | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Choe, Jae Gol | - |
dc.date.accessioned | 2021-09-04T02:55:52Z | - |
dc.date.available | 2021-09-04T02:55:52Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89530 | - |
dc.description.abstract | Objectives To investigate the role of functional visceral fat activity assessed by preoperative F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) in colorectal cancer (CRC) for predicting regional lymph node (LN) or distant metastasis. Method We evaluated 131 patients with newly diagnosed CRC. They all underwent pre-operative 18F-FDG PET/CT and surgery. Functional fat activity was measured by maximum standardized uptake value (SUVmax) using 18F-FDG PET/CT. Functional visceral fat activity was measured by SUVmax of visceral fat/SUVmax of subcutaneous fat (V/S) ratio. Mann-Whitney U test, chi(2) test, Fisher's exact test, receiver-operating characteristic (ROC) analysis, Spearrman's correlation coefficient, and uni- and multivariate logistic regression statistical analyses were done. Results Patients with higher V/S ratio displayed a significantly higher rate of regional LN (p = 0.004) and distant metastasis (p<0.001). In addition, V/S ratio was the only factor that was significantly associated with distant metastasis. An optimal cut-off V/S ratio of 1.88 was proposed for predicting distant metastasis with a sensitivity of 84.6% and specificity of 78.8% (area under the curve: 0.86; p<0.0001) Conclusion Functional visceral fat activity is significantly associated with distant metastasis in CRC patients. Furthermore, V/S ratio can be useful as a complementary factor in predicting distant metastasis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | METABOLIC-ACTIVITY | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | OBESITY | - |
dc.subject | INFLAMMATION | - |
dc.title | Predictive Role of Functional Visceral Fat Activity Assessed by Preoperative F-18 FDG PET/CT for Regional Lymph Node or Distant Metastasis in Patients with Colorectal Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Choe, Jae Gol | - |
dc.identifier.doi | 10.1371/journal.pone.0148776 | - |
dc.identifier.scopusid | 2-s2.0-84959421659 | - |
dc.identifier.wosid | 000370046600106 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.11, no.2 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | METABOLIC-ACTIVITY | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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