Glabretal-type triterpenoid from the root bark of Dictamnus dasycarpus ameliorates collagen-induced arthritis by inhibiting Erk-dependent lymphocyte proliferation
DC Field | Value | Language |
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dc.contributor.author | Choi, Sang-Pil | - |
dc.contributor.author | Choi, Chang-Yong | - |
dc.contributor.author | Park, Kyungmin | - |
dc.contributor.author | Kim, Nahyun | - |
dc.contributor.author | Moon, Hyun-Seuk | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.accessioned | 2021-09-04T03:05:56Z | - |
dc.date.available | 2021-09-04T03:05:56Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02-03 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89549 | - |
dc.description.abstract | Ethnopharmacological relevance: The root bark of Dictamnus dasycarpus Turcz. (Rutaceae) has been used as a traditional herbal medicine to treat various inflammatory diseases in East Asia. We have showed previously that a glabretal type triterpenoid (dictabretol A) from D. dasycarpus root bark has immunosuppressive activity. Aim of the study: This study was conducted to define the molecular mechanism of how dictabretol A inhibits lymphocyte proliferation and to evaluate the therapeutic efficacy of dictabretol A in an animal model of rheumatoid arthritis. Materials and methods: Various murine immune cells (T cells, B cells, and macrophages) and splenocytes were used to study the anti-proliferative effect of dictabretol A in vitro. A collagen-induced arthritis model was also used to examine the therapeutic effect of dictabretol A in vivo. Results: Dictabretol A specifically inhibited lymphocyte proliferation by blocking the cell cycle transition from the G(1) to the S phase. This effect was achieved by blocking Erk1/2, nuclear factor kappa B, and the C-myc axis of cell cycle progression. Further dictabretol A treatment alleviated the severity of collagen induced arthritis. Conclusion: Our results reveal the molecular mechanism for the anti-lymphoproliferative effect of dictabretol A and show the therapeutic efficacy of dictabretol A for rheumatoid arthritis. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | CELL-CYCLE PROGRESSION | - |
dc.subject | KINASE | - |
dc.subject | ALPHA | - |
dc.subject | BETA | - |
dc.subject | MYC | - |
dc.title | Glabretal-type triterpenoid from the root bark of Dictamnus dasycarpus ameliorates collagen-induced arthritis by inhibiting Erk-dependent lymphocyte proliferation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Moon, Hyun-Seuk | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.contributor.affiliatedAuthor | Chun, Taehoon | - |
dc.identifier.doi | 10.1016/j.jep.2015.10.043 | - |
dc.identifier.scopusid | 2-s2.0-84954123492 | - |
dc.identifier.wosid | 000370108900003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.178, pp.13 - 16 | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 178 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | MYC | - |
dc.subject.keywordAuthor | Cell cycle | - |
dc.subject.keywordAuthor | Collagen induced arthritis | - |
dc.subject.keywordAuthor | Dictabretol A | - |
dc.subject.keywordAuthor | Lymphocyte | - |
dc.subject.keywordAuthor | Signal transduction | - |
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