Noninvasive biomarkers for acute hepatotoxicity induced by 1,3-dichloro-2-propanol: hyperpolarized C-13 dynamic MR spectroscopy
DC Field | Value | Language |
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dc.contributor.author | Kim, Gwang-Won | - |
dc.contributor.author | Oh, Chang-Hyun | - |
dc.contributor.author | Kim, Jong-Choon | - |
dc.contributor.author | Yoon, Woong | - |
dc.contributor.author | Jeong, Yong-Yeon | - |
dc.contributor.author | Kim, Yun-Hyeon | - |
dc.contributor.author | Kim, Jae-Kyu | - |
dc.contributor.author | Park, Jin-Gyoon | - |
dc.contributor.author | Kang, Heoung-Keun | - |
dc.contributor.author | Jeong, Gwang-Woo | - |
dc.date.accessioned | 2021-09-04T03:25:34Z | - |
dc.date.available | 2021-09-04T03:25:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0730-725X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89635 | - |
dc.description.abstract | The purpose of this study was to investigate the cellular metabolite change for acute hepatotoxicity induced by 1,3-dichloro-2-propanol (1,3-DCP) in rats and its correlations with the enzyme levels. In order to induce acute hepatotoxicity, a single subcutaneous injection of 1,3-DCP (80 mg/kg) was given to six male Sprague-Dawley rats. Hyperpolarized C-13 dynamic magnetic resonance spectroscopy (MRS) was performed on rat liver following injection of hyperpolarized [1-C-13] pyruvate. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in the 1,3-DCP treated rats were significantly increased as compared with those in normal rats. In the dynamic C-13 MR spectra, the ratios of [1-C-13] lactate to the total carbon and [1-C-13] alanine to the total carbon in the 1,3-DCP treated rats were significantly increased, and there were positive correlations between cellular metabolic changes and enzyme levels. The levels of [1-C-13] lactate and [1-C-13] alanine are potentially considered as important biomarkers for the 1,3-DCP-induced acute hepatotoxicity. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | MAGNETIC-RESONANCE-SPECTROSCOPY | - |
dc.subject | IN-VIVO | - |
dc.subject | RAT-LIVER | - |
dc.subject | CANCER | - |
dc.subject | ELEVATION | - |
dc.subject | TOXICITY | - |
dc.subject | PYRUVATE | - |
dc.subject | MOUSE | - |
dc.subject | MODEL | - |
dc.subject | TIMES | - |
dc.title | Noninvasive biomarkers for acute hepatotoxicity induced by 1,3-dichloro-2-propanol: hyperpolarized C-13 dynamic MR spectroscopy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Chang-Hyun | - |
dc.identifier.doi | 10.1016/j.mri.2015.10.023 | - |
dc.identifier.scopusid | 2-s2.0-84954207515 | - |
dc.identifier.wosid | 000368312600013 | - |
dc.identifier.bibliographicCitation | MAGNETIC RESONANCE IMAGING, v.34, no.2, pp.159 - 165 | - |
dc.relation.isPartOf | MAGNETIC RESONANCE IMAGING | - |
dc.citation.title | MAGNETIC RESONANCE IMAGING | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 159 | - |
dc.citation.endPage | 165 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE-SPECTROSCOPY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RAT-LIVER | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ELEVATION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PYRUVATE | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | TIMES | - |
dc.subject.keywordAuthor | Hyperpolarized C-13 | - |
dc.subject.keywordAuthor | Dynamic nuclear polarization (DNP) | - |
dc.subject.keywordAuthor | Cellular metabolism | - |
dc.subject.keywordAuthor | 1,3-dichloro-2-propanol(1,3-DCP) | - |
dc.subject.keywordAuthor | Hepatotoxicity | - |
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