Modulation of Charge Density of Cationic Conjugated Polyelectrolytes for Improving the FRET-Induced Sensory Signal with Enhanced On/Off Ratio
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ji-Eun | - |
dc.contributor.author | Jung, In Hwan | - |
dc.contributor.author | Kim, Boram | - |
dc.contributor.author | Le, Van Sang | - |
dc.contributor.author | Woo, Han Young | - |
dc.date.accessioned | 2021-09-04T03:30:39Z | - |
dc.date.available | 2021-09-04T03:30:39Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1022-1352 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89676 | - |
dc.description.abstract | Three types of cationic polyfluorenes with a different number of ionic groups are synthesized to modulate their solubility in water and the interactions with anionic oligonucleotide probes (DNA-C). Increasing the charge density improves the water-solubility of conjugated polyelectrolytes (CPEs) but decreases its optical antenna effect in the electrostatic sensory platform (CPE/DNA-C), resulting in low fluorescence resonance energy transfer (FRET) signal. With increasing charge density in CPE, the concentration of conjugated units in CPE/DNA-C decreases at [+]:[-] = 1:1, after which little driving force is expected to bring positive CPEs and negative DNA-C into close proximity for efficient FRET. CPF2 with 2 ionic groups (per repeat unit) and hydrophilic polyether side-chains exhibits good water-solubility and a higher FRET signal with an enhanced signal on/off ratio. In addition, the charge density in CPEs modulates the range of sensory responses by forming a tighter or weaker electrostatic CPE/DNA-C complex, which perturbs the probe-target binding interactions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | RESONANCE ENERGY-TRANSFER | - |
dc.subject | POLYMERS | - |
dc.subject | WATER | - |
dc.subject | DYNAMICS | - |
dc.subject | APTAMER | - |
dc.subject | SINGLE | - |
dc.subject | RANGE | - |
dc.subject | AMPLIFICATION | - |
dc.subject | SENSITIVITY | - |
dc.title | Modulation of Charge Density of Cationic Conjugated Polyelectrolytes for Improving the FRET-Induced Sensory Signal with Enhanced On/Off Ratio | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Woo, Han Young | - |
dc.identifier.doi | 10.1002/macp.201500304 | - |
dc.identifier.scopusid | 2-s2.0-84955299391 | - |
dc.identifier.wosid | 000369769800014 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR CHEMISTRY AND PHYSICS, v.217, no.3, pp.459 - 466 | - |
dc.relation.isPartOf | MACROMOLECULAR CHEMISTRY AND PHYSICS | - |
dc.citation.title | MACROMOLECULAR CHEMISTRY AND PHYSICS | - |
dc.citation.volume | 217 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 466 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | RESONANCE ENERGY-TRANSFER | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | APTAMER | - |
dc.subject.keywordPlus | SINGLE | - |
dc.subject.keywordPlus | RANGE | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordAuthor | conjugated polyelectrolytes | - |
dc.subject.keywordAuthor | fluorescence resonance energy transfer | - |
dc.subject.keywordAuthor | ionic density | - |
dc.subject.keywordAuthor | on | - |
dc.subject.keywordAuthor | off ratio | - |
dc.subject.keywordAuthor | water-solubility | - |
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