Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study
- Authors
- Chung, Hye Soo; Lee, Min Jung; Hwang, Soon Young; Lee, Hyun Jung; Yoo, Hye Jin; Seo, Ji-A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Dong Seop; Kim, Seon Mi; Choi, Kyung Mook
- Issue Date
- 6-1월-2016
- Publisher
- BMC
- Keywords
- ANGPTL3; ANGPTL8; Cholesterol; Dyslipidemias; HDL; LDL; Triglycerides
- Citation
- CARDIOVASCULAR DIABETOLOGY, v.15
- Indexed
- SCIE
SCOPUS
- Journal Title
- CARDIOVASCULAR DIABETOLOGY
- Volume
- 15
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89827
- DOI
- 10.1186/s12933-015-0324-y
- ISSN
- 1475-2840
- Abstract
- Background: Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic beta-cells and induces insulin secretion. However, there are no previous longitudinal studies in humans. Methods: We analyzed the age-and sex-matched data of 240 normal weight and overweight Korean children from the Korean Metabolic disorders and Obesity Study in Elementary School children (K-MOSES), a prospective observational cohort study. Results: At baseline, ANGPTL8 concentrations were positively associated with triglycerides (TG) (r = 0.168, P = 0.010), whereas ANGPTL3 levels were associated with fasting insulin (r = 0.248, P < 0.001) and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.197, P = 0.002). Although both ANGPTL8 and ANGPTL3 levels did not differ between children with normal weight and children with overweight, ANGPTL8 levels were increased in males compared to females (341.2 [267.4-436.5] vs. 270.2 [213.9-378.8] pg/ml, P = 0.001). In particular, there was no significant inter-relationship between circulating ANGPTL8 and ANGPTL3 concentrations in Korean boys and girls (r = -0.073, P = 0.265). Multivariate analysis showed that baseline ANGPTL8 concentrations were independently associated with future changes of serum TG levels in Korean children after adjusting for confounding factors after a 3 year follow-up period (r = -0.165, P = 0.016).
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- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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