Common variants in DRD2 are associated with sleep duration: the CARe consortium
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cade, Brian E. | - |
dc.contributor.author | Gottlieb, Daniel J. | - |
dc.contributor.author | Lauderdale, Diane S. | - |
dc.contributor.author | Bennett, David A. | - |
dc.contributor.author | Buchman, Aron S. | - |
dc.contributor.author | Buxbaum, Sarah G. | - |
dc.contributor.author | De Jager, Philip L. | - |
dc.contributor.author | Evans, Daniel S. | - |
dc.contributor.author | Fueloep, Tibor | - |
dc.contributor.author | Gharib, Sina A. | - |
dc.contributor.author | Johnson, W. Craig | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Larkin, Emma K. | - |
dc.contributor.author | Lee, Seung Ku | - |
dc.contributor.author | Lim, Andrew S. | - |
dc.contributor.author | Punjabi, Naresh M. | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Stone, Katie L. | - |
dc.contributor.author | Tranah, Gregory J. | - |
dc.contributor.author | Weng, Jia | - |
dc.contributor.author | Yaffe, Kristine | - |
dc.contributor.author | Zee, Phyllis C. | - |
dc.contributor.author | Patel, Sanjay R. | - |
dc.contributor.author | Zhu, Xiaofeng | - |
dc.contributor.author | Redline, Susan | - |
dc.contributor.author | Saxena, Richa | - |
dc.date.accessioned | 2021-09-04T04:16:32Z | - |
dc.date.available | 2021-09-04T04:16:32Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-01-01 | - |
dc.identifier.issn | 0964-6906 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89866 | - |
dc.description.abstract | Sleep duration is implicated in the etiologies of chronic diseases and premature mortality. However, the genetic basis for sleep duration is poorly defined. We sought to identify novel genetic components influencing sleep duration in a multi-ethnic sample. Meta-analyses were conducted of genetic associations with self-reported, habitual sleep duration from seven Candidate Gene Association Resource (CARe) cohorts of over 25 000 individuals of African, Asian, European and Hispanic American ancestry. All individuals were genotyped for similar to 50 000 SNPs from 2000 candidate heart, lung, blood and sleep genes. African-Americans had additional genome-wide genotypes. Four cohorts provided replication. A SNP (rs17601612) in the dopamine D2 receptor gene (DRD2) was significantly associated with sleep duration (P = 9.8 x 10(-7)). Conditional analysis identified a second DRD2 signal with opposite effects on sleep duration. In exploratory analysis, suggestive association was observed for rs17601612 with polysomnographically determined sleep latency (P = 0.002). The lead DRD2 signal was recently identified in a schizophrenia GWAS, and a genetic risk score of 11 additional schizophrenia GWAS loci genotyped on the IBC array was also associated with longer sleep duration (P = 0.03). These findings support a role for DRD2 in influencing sleep duration. Our work motivates future pharmocogenetics research on alerting agents such as caffeine and modafinil that interact with the dopaminergic pathway and further investigation of genetic overlap between sleep and neuro-psychiatric traits. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | D2 RECEPTOR GENE | - |
dc.subject | HUMAN-BRAIN | - |
dc.subject | DOPAMINE-RECEPTORS | - |
dc.subject | OSTEOPOROTIC FRACTURES | - |
dc.subject | ADENOSINE A(2A) | - |
dc.subject | HUMAN STRIATUM | - |
dc.subject | METAANALYSIS | - |
dc.subject | DESIGN | - |
dc.subject | LOCI | - |
dc.title | Common variants in DRD2 are associated with sleep duration: the CARe consortium | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Seung Ku | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.1093/hmg/ddv434 | - |
dc.identifier.scopusid | 2-s2.0-84962181759 | - |
dc.identifier.wosid | 000372147800014 | - |
dc.identifier.bibliographicCitation | HUMAN MOLECULAR GENETICS, v.25, no.1, pp.167 - 179 | - |
dc.relation.isPartOf | HUMAN MOLECULAR GENETICS | - |
dc.citation.title | HUMAN MOLECULAR GENETICS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 167 | - |
dc.citation.endPage | 179 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | D2 RECEPTOR GENE | - |
dc.subject.keywordPlus | HUMAN-BRAIN | - |
dc.subject.keywordPlus | DOPAMINE-RECEPTORS | - |
dc.subject.keywordPlus | OSTEOPOROTIC FRACTURES | - |
dc.subject.keywordPlus | ADENOSINE A(2A) | - |
dc.subject.keywordPlus | HUMAN STRIATUM | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | LOCI | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.