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Bottom-Up Engineering of Well-Defined 3D Microtissues Using Microplatforms and Biomedical Applications

Authors
Lee, Geon HuiLee, Jae SeoWang, XiaohongLee, Sang Hoon
Issue Date
1월-2016
Publisher
WILEY
Keywords
3D cultures; Microtissue; Regenerative medicine; Self-assembly; Tissue engineering
Citation
ADVANCED HEALTHCARE MATERIALS, v.5, no.1, pp.56 - 74
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED HEALTHCARE MATERIALS
Volume
5
Number
1
Start Page
56
End Page
74
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/89951
DOI
10.1002/adhm.201500107
ISSN
2192-2640
Abstract
During the last decades, the engineering of well-defined 3D tissues has attracted great attention because it provides in vivo mimicking environment and can be a building block for the engineering of bioartificial organs. In this Review, diverse engineering methods of 3D tissues using microscale devices are introduced. Recent progress of microtechnologies has enabled the development of microplatforms for bottom-up assembly of diverse shaped 3D tissues consisting of various cells. Micro hanging-drop plates, microfluidic chips, and arrayed microwells are the typical examples. The encapsulation of cells in hydrogel microspheres and microfibers allows the engineering of 3D microtissues with diverse shapes. Applications of 3D microtissues in biomedical fields are described, and the future direction of microplatform-based engineering of 3D micro-tissues is discussed.
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