Low-dose adjunctive cilostazol in patients with complex lesions undergoing percutaneous coronary intervention
DC Field | Value | Language |
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dc.contributor.author | Zheng, Xin-Tian | - |
dc.contributor.author | Chen, Kang-Yin | - |
dc.contributor.author | Liu, Tong | - |
dc.contributor.author | Xu, Ling-Xia | - |
dc.contributor.author | Che, Jing-Jin | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Li, Guang-Ping | - |
dc.date.accessioned | 2021-09-04T04:41:44Z | - |
dc.date.available | 2021-09-04T04:41:44Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 0305-1870 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90031 | - |
dc.description.abstract | Patients with complex coronary lesions undergoing percutaneous coronary intervention (PCI) have more major adverse cardiac events (MACE) than do those with simpler cases. Therefore, intensive antiplatelet therapy might be needed in these patients. A total of 127 patients with complex lesions undergoing PCI in the Second Hospital of Tianjin Medical University from October 2012 to April 2014 were randomized to receive either dual (aspirin plus clopidogrel, DAPT, n = 66), or triple antiplatelet therapy (aspirin plus clopidogrel plus cilostazol; TAPT, n = 61). Patients in the TAPT group received low-dose cilostazol (100 mg loading, followed with 50 mg twice per day) for 3-6 months. The primary endpoint was composite MACE. The complex coronary target lesions were defined as at least one of the following: left main disease; severe 3-vessel disease; chronic total occlusion lesions; true bifurcation lesion; ostial lesions; severe calcified lesions; and highly thrombotic lesions. The two groups had similar baseline clinical and angiographic characteristics. One-year clinical outcomes showed that the TAPT group had significantly lower incidences of myocardial infarction (1.6% vs 13.6%, P = 0.018) and MACE (1.6% vs 16.7%, P = 0.004) than DAPT group. The DAPT group had two cases of stent thrombosis, while the TAPT group did not. Furthermore, adjunctive low-dose cilostazol didn't significantly increase the incidence of bleeding events (26.2% vs 19.7%, P = 0.381) regardless of major (4.9% vs 4.5%, P = 0.921) or minor (21.3% vs 15.2%, P = 0.368) bleeding events. In conclusion, low-dose adjunctive cilostazol seems superior to dual antiplatelet therapy in reducing recurrent ischemic events in patients with complex coronary lesions and the two test groups have a similar incidence of bleeding events. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | DUAL ANTIPLATELET THERAPY | - |
dc.subject | DRUG-ELUTING STENT | - |
dc.subject | ELEVATION MYOCARDIAL-INFARCTION | - |
dc.subject | REDUCES LATE RESTENOSIS | - |
dc.subject | DIABETIC-PATIENTS | - |
dc.subject | CARDIAC-SURGERY | - |
dc.subject | LEFT MAIN | - |
dc.subject | IMPLANTATION | - |
dc.subject | DISEASE | - |
dc.subject | TRIPLE | - |
dc.title | Low-dose adjunctive cilostazol in patients with complex lesions undergoing percutaneous coronary intervention | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.1111/1440-1681.12495 | - |
dc.identifier.scopusid | 2-s2.0-84954413926 | - |
dc.identifier.wosid | 000368345800004 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.43, no.1, pp.29 - 33 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.endPage | 33 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | DUAL ANTIPLATELET THERAPY | - |
dc.subject.keywordPlus | DRUG-ELUTING STENT | - |
dc.subject.keywordPlus | ELEVATION MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | REDUCES LATE RESTENOSIS | - |
dc.subject.keywordPlus | DIABETIC-PATIENTS | - |
dc.subject.keywordPlus | CARDIAC-SURGERY | - |
dc.subject.keywordPlus | LEFT MAIN | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TRIPLE | - |
dc.subject.keywordAuthor | cilostazol | - |
dc.subject.keywordAuthor | complex coronary lesions | - |
dc.subject.keywordAuthor | dual antiplatelet therapy | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
dc.subject.keywordAuthor | triple antiplatelet therapy | - |
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