Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: systematic review and meta-analysis
- Authors
- Kim, Jun H.; Lee, Kyung H.; Kim, Kyoung-Tae; Kim, Hyun J.; Ahn, Hyeong S.; Kim, Yeo J.; Lee, Ha Y.; Jeon, Yong S.
- Issue Date
- 2016
- Publisher
- BRITISH INST RADIOLOGY
- Citation
- BRITISH JOURNAL OF RADIOLOGY, v.89, no.1068
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRITISH JOURNAL OF RADIOLOGY
- Volume
- 89
- Number
- 1068
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90199
- DOI
- 10.1259/bjr.20160421
- ISSN
- 0007-1285
- Abstract
- Objective: To compare the diagnostic accuracy of digital tomosynthesis (DTS) with that of chest radiography for the detection of pulmonary nodules by meta-analysis. Methods: A systematic literature search was performed to identify relevant original studies from 1 January 1 1976 to 31 August 31 2016. The quality of included studies was assessed by quality assessment of diagnostic accuracy studies-2. Per-patient data were used to calculate the sensitivity and specificity and per-lesion data were used to calculate the detection rate. Summary receiver-operating characteristic curves were drawn for pulmonary nodule detection. Results: 16 studies met the inclusion criteria. 1017 patients on a per-patient basis and 2159 lesions on a per-lesion basis from 16 eligible studies were evaluated. The pooled patient-based sensitivity of DTS was 0.85 [95% confidence interval (CI) 0.83-0.88] and the specificity was 0.95 (0.93-0.96). The pooled sensitivity and specificity of chest radiography were 0.47 (0.44-0.51) and 0.37 (0.34-0.40), respectively. The per-lesion detection rate was 2.90 (95% CI 2.63-3.19). Conclusion: DTS has higher diagnostic accuracy than chest radiography for detection of pulmonary nodules. Chest radiography has low sensitivity but similar specificity, comparable with that of DTS. Advances in knowledge: DTS has higher diagnostic accuracy than chest radiography for the detection of pulmonary nodules.
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