Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
DC Field | Value | Language |
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dc.contributor.author | Kim, Jiyeon | - |
dc.contributor.author | Kim, Seong Hoon | - |
dc.contributor.author | Lim, Sung Chul | - |
dc.contributor.author | Kim, Woojun | - |
dc.contributor.author | Shon, Young-Min | - |
dc.date.accessioned | 2021-09-04T05:08:40Z | - |
dc.date.available | 2021-09-04T05:08:40Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1176-6328 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90209 | - |
dc.description.abstract | Purpose: To evaluate the evolution of nonlesional temporal lobe epilepsy (TLE-NL) in patients treated exclusively with antiepileptic drugs and to elucidate clinical phenotypes related to the prognosis of these patients. Methods: Clinical, radiological, and electroencephalographic (EEG) findings in 84 patients with TLE-NL were reviewed. A good response group (GRG) and a poor response group (PRG) were defined if the duration of their seizure-free period was >1 year, or <1 year, respectively. Results: There were 46 (54.8%) patients in the GRG and 38 (45.2%) patients in the PRG. The number of antiepileptic drugs administered was significantly lower in the GRG than that in the PRG (1.3 +/- 0.8 vs 2.8 +/- 1.0, respectively; P<0.05). The GRG had a significantly older age of onset than the PRG and a lower occurrence of initial precipitating events, such as febrile seizures, central nervous system infection, and head trauma (P<0.05). The prevalence of EEG abnormality, presence of aura, generalized seizures, and automatism was less frequently observed in the GRG (P<0.05). Multivariate analysis showed that the presence of automatism and initial precipitating events were significantly associated with a poor prognosis (P<0.05). Conclusion: In contrast to the commonly assumed intractability of TLE, we found that more than 54% of patients with TLE-NL achieved a long seizure-free period. Older age at onset of TLE-NL was associated with a better prognosis. However, the presence of automatism and initial precipitating events were related to a poor prognosis. Future prospective studies with a much larger population are warranted. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.subject | MAJOR PROGNOSTIC-FACTOR | - |
dc.subject | UNDERLYING CAUSE | - |
dc.subject | AUTOMATISMS | - |
dc.subject | RECURRENCE | - |
dc.subject | SCLEROSIS | - |
dc.subject | ONSET | - |
dc.title | Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jiyeon | - |
dc.identifier.doi | 10.2147/NDT.S110400 | - |
dc.identifier.scopusid | 2-s2.0-84983527678 | - |
dc.identifier.wosid | 000380523100001 | - |
dc.identifier.bibliographicCitation | NEUROPSYCHIATRIC DISEASE AND TREATMENT, v.12, pp.1887 - 1891 | - |
dc.relation.isPartOf | NEUROPSYCHIATRIC DISEASE AND TREATMENT | - |
dc.citation.title | NEUROPSYCHIATRIC DISEASE AND TREATMENT | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 1887 | - |
dc.citation.endPage | 1891 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MAJOR PROGNOSTIC-FACTOR | - |
dc.subject.keywordPlus | UNDERLYING CAUSE | - |
dc.subject.keywordPlus | AUTOMATISMS | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | SCLEROSIS | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordAuthor | epilepsy | - |
dc.subject.keywordAuthor | benign temporal lobe epilepsy | - |
dc.subject.keywordAuthor | nonlesional temporal lobe epilepsy | - |
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