Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
- Authors
- Oh, Keun Sang; Kim, Kyungim; Yoon, Byeong Deok; Lee, Hye Jin; Park, Dal Yong; Kim, Eun-yeong; Lee, Kiho; Seo, Jae Hong; Yuk, Soon Hong
- Issue Date
- 2016
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- multilayer nanoparticles; Solutol; Pluronic F-68; docetaxel; cancer therapy
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.11, pp.1077 - 1087
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 11
- Start Page
- 1077
- End Page
- 1087
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90216
- DOI
- 10.2147/IJN.S100170
- ISSN
- 1176-9114
- Abstract
- A mixture of docetaxel (DTX) and Solutol (R) HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (similar to 11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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