Antiviral effects of black raspberry (Rubus coreanus) seed extract and its polyphenolic compounds on norovirus surrogates
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Hye | - |
dc.contributor.author | Bae, Sun Young | - |
dc.contributor.author | Oh, Mi | - |
dc.contributor.author | Seok, Jong Hyeon | - |
dc.contributor.author | Kim, Sella | - |
dc.contributor.author | Bin Chung, Yeon | - |
dc.contributor.author | Gowda, Giri K. | - |
dc.contributor.author | Mun, Ji Young | - |
dc.contributor.author | Chung, Mi Sook | - |
dc.contributor.author | Kim, Kyung Hyun | - |
dc.date.accessioned | 2021-09-04T05:11:55Z | - |
dc.date.available | 2021-09-04T05:11:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90234 | - |
dc.description.abstract | Black raspberry seeds, a byproduct of wine and juice production, contain large quantities of polyphenolic compounds. The antiviral effects of black raspberry seed extract (RCS) and its fraction with molecular weight less than 1 kDa (RCS-F1) were examined against food-borne viral surrogates, murine norovirus-1 (MNV-1) and feline calicivirus-F9 (FCV-F9). The maximal antiviral effect was achieved when RCS or RCS-F1 was added simultaneously to cells with MNV-1 or FCV-F9, reaching complete inhibition at 0.1-1 mg/mL. Transmission electron microscopy (TEM) images showed enlarged viral capsids or disruption (from 35 nm to up to 100 nm) by RCS-F1. Our results thus suggest that RCS-F1 can interfere with the attachment of viral surface protein to host cells. Further, two polyphenolic compounds derived from RCS-F1, cyanidin-3-glucoside (C3G) and gallic acid, identified by liquid chromatography-tandem mass spectrometry, showed inhibitory effects against the viruses. C3G was suggested to bind to MNV-1 RNA polymerase and to enlarge viral capsids using differential scanning fluorimetry and TEM, respectively. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | FOODBORNE VIRAL SURROGATES | - |
dc.subject | PROMOTE PROTEIN STABILITY | - |
dc.subject | DEPENDENT RNA-POLYMERASE | - |
dc.subject | HUMAN ENTERIC VIRUSES | - |
dc.subject | MURINE NOROVIRUS | - |
dc.subject | FELINE CALICIVIRUS | - |
dc.subject | CRYSTAL-STRUCTURES | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IN-VITRO | - |
dc.subject | JUICE | - |
dc.title | Antiviral effects of black raspberry (Rubus coreanus) seed extract and its polyphenolic compounds on norovirus surrogates | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ji-Hye | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hyun | - |
dc.identifier.doi | 10.1080/09168451.2016.1151337 | - |
dc.identifier.scopusid | 2-s2.0-84975138749 | - |
dc.identifier.wosid | 000379185400025 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.80, no.6, pp.1196 - 1204 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 80 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1196 | - |
dc.citation.endPage | 1204 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | FOODBORNE VIRAL SURROGATES | - |
dc.subject.keywordPlus | PROMOTE PROTEIN STABILITY | - |
dc.subject.keywordPlus | DEPENDENT RNA-POLYMERASE | - |
dc.subject.keywordPlus | HUMAN ENTERIC VIRUSES | - |
dc.subject.keywordPlus | MURINE NOROVIRUS | - |
dc.subject.keywordPlus | FELINE CALICIVIRUS | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | JUICE | - |
dc.subject.keywordAuthor | antiviral activity | - |
dc.subject.keywordAuthor | murine norovirus | - |
dc.subject.keywordAuthor | feline calicivirus | - |
dc.subject.keywordAuthor | black raspberry seed extract | - |
dc.subject.keywordAuthor | cyanidin-3-glucoside | - |
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