Day/night difference in extradural cortical stimulation for motor relearning in a subacute stroke rat model
- Authors
- Kim, Joo Yeon; Sun, Woong; Park, Eunhee; Lee, Jiyeong; Kim, Hyun; Shin, Yong-Il; Kim, Yun-Hee; Chang, Won Hyuk
- Issue Date
- 2016
- Publisher
- IOS PRESS
- Keywords
- Day/night; extradural cortical stimulation; electrical stimulation; motor learning; motor recovery; stroke
- Citation
- RESTORATIVE NEUROLOGY AND NEUROSCIENCE, v.34, no.3, pp.379 - 387
- Indexed
- SCIE
SCOPUS
- Journal Title
- RESTORATIVE NEUROLOGY AND NEUROSCIENCE
- Volume
- 34
- Number
- 3
- Start Page
- 379
- End Page
- 387
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90248
- DOI
- 10.3233/RNN-150593
- ISSN
- 0922-6028
- Abstract
- Purpose: The aim of this study was to assess the proper timing of extradural cortical stimulation (ECS) on the motor relearning in a rat model of subacute photothrombotic stroke. Methods: Photothrombotic infarction was induced on the dominant sensorimotor cortex in male Sprague-Dawley rats after training in a single-pellet reaching task (SPRT). Rats were randomly divided into three groups after stroke: ECS during the inactive period (Day-ECS group), ECS during the active period (Night-ECS group) and no ECS (Non -stimulated group). Six sham -operated rats were assigned to the control group. The Day-and Night-ECS group received continuous ECS for 12 hours during the day or night for 2 weeks from day 4 after the stroke. Behavioral assessment with SPRT was performed daily. Results: SPRT showed a significantly faster and greater improvement in the Day and Night-ECS groups than in the Non stimulated group. In the Day- and Night-ECS groups, the success rate of SPRT differed significantly from Non -stimulated group on day 11 and day 8, respectively. In addition, the Night-ECS group showed a significantly higher SPRT success rate than the Day-ECS group from days 10 to 13. Conclusion: ECS during the active period might be more effective for motor relearning in the subacute stroke rat model.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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