Continuous distraction-induced delayed spinal cord injury on motor-evoked potentials and histological changes of spinal cord in a porcine model
DC Field | Value | Language |
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dc.contributor.author | Hong, J-Y | - |
dc.contributor.author | Suh, S-W | - |
dc.contributor.author | Lee, S-H | - |
dc.contributor.author | Park, J-H | - |
dc.contributor.author | Park, S-Y | - |
dc.contributor.author | Rhyu, I. J. | - |
dc.contributor.author | Yang, J-H | - |
dc.date.accessioned | 2021-09-04T05:21:21Z | - |
dc.date.available | 2021-09-04T05:21:21Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1362-4393 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90308 | - |
dc.description.abstract | Study design: Experimental study. Objectives: This study evaluated distraction-induced delayed spinal cord injury in a porcine model. Setting: Department of Orthopedics, Korea University Guro Hospital, Seoul, Korea. Methods: Global osteotomy of three columns was performed on the thirteenth thoracic vertebrae with 13 pigs. The osteotomized vertebrae were distracted to 57-103% of segmental vertebral height (SVH) length, which was less than the distraction length that induces prompt SCI. The vertebral height was maintained until the loss of motor-evoked potential (MEP) signals with continuous distraction. The distraction distance and the time at which SCI occurred were measured, and distraction was then released to observe MEP recovery patterns. Results: We found delayed SCI in 8 of the 12 pigs, with a mean 20.9mm (range 19-25mm) and 10.7 min (range 8-12 min) of continuous spinal distraction, which was equivalent to 74.3% (68-84%) of SVH and 3.63% (3.42-4.31%) of thoracolumbar spinal length. A continuous 74.3% SVH distraction over an average of 10.7 min caused a delayed SCI, which was indicated by mild histologic changes in the spinal cord. Recovery patterns from SCI after distraction release were compatible with the degree of histological change; however, these patterns differed from the previously investigated prompt type of SCI. Conclusion: Late onset injury due to continuous spinal distraction, which is comparable to iatrogenic SCI in spinal correction surgery, is important for understanding the impact of corrective surgery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | TRANSCRANIAL ELECTRICAL-STIMULATION | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | IDIOPATHIC SCOLIOSIS | - |
dc.subject | SEGMENTAL ARTERIES | - |
dc.subject | SURGERY | - |
dc.subject | DEFORMITY | - |
dc.subject | PIGS | - |
dc.subject | RAT | - |
dc.title | Continuous distraction-induced delayed spinal cord injury on motor-evoked potentials and histological changes of spinal cord in a porcine model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, J-Y | - |
dc.contributor.affiliatedAuthor | Park, J-H | - |
dc.contributor.affiliatedAuthor | Rhyu, I. J. | - |
dc.identifier.doi | 10.1038/sc.2015.231 | - |
dc.identifier.scopusid | 2-s2.0-84954520286 | - |
dc.identifier.wosid | 000383581400004 | - |
dc.identifier.bibliographicCitation | SPINAL CORD, v.54, no.9, pp.649 - 655 | - |
dc.relation.isPartOf | SPINAL CORD | - |
dc.citation.title | SPINAL CORD | - |
dc.citation.volume | 54 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 649 | - |
dc.citation.endPage | 655 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Rehabilitation | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Rehabilitation | - |
dc.subject.keywordPlus | TRANSCRANIAL ELECTRICAL-STIMULATION | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | IDIOPATHIC SCOLIOSIS | - |
dc.subject.keywordPlus | SEGMENTAL ARTERIES | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | DEFORMITY | - |
dc.subject.keywordPlus | PIGS | - |
dc.subject.keywordPlus | RAT | - |
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