Understanding structural characteristics of out-of-register hIAPP amyloid proteins via molecular dynamics
DC Field | Value | Language |
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dc.contributor.author | Baek, Inchul | - |
dc.contributor.author | Lee, Myeongsang | - |
dc.contributor.author | Na, Sungsoo | - |
dc.date.accessioned | 2021-09-04T05:34:18Z | - |
dc.date.available | 2021-09-04T05:34:18Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90411 | - |
dc.description.abstract | Amyloid oligomers are implicated in several neurodegenerative diseases; studies have shown oligomeric amyloids form fibrillary amyloids and have toxic effects on cell function. Several experimental and computational studies have investigated in-register amyloids and their characteristics. However, recently, out-of-register amyloid structures have been observed and their inherent weak structural stability exhibits higher toxicity under physiological conditions compared to that of in-register amyloids. Specifically, by varying the size of oligomeric hIAPP out-of-register structures from 4 layers to 20 layers, we successfully analyzed the structural characteristics of fibrillary out-of-register hIAPP; the critical structure size of out-of-register hIAPP is related to fibrillar growth from protofibrils. Through the structural analysis of out-of-register hIAPP, we shed light on the fibrillar growth mechanism of out-of-register hIAPP oligomer in detail. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | MECHANICAL RESPONSE | - |
dc.subject | BETA-SHEETS | - |
dc.subject | IN-VITRO | - |
dc.subject | FIBRILS | - |
dc.subject | POLYPEPTIDE | - |
dc.subject | STABILITY | - |
dc.subject | DISEASE | - |
dc.subject | MODELS | - |
dc.subject | BETA(2)-MICROGLOBULIN | - |
dc.subject | PROTOFIBRILS | - |
dc.title | Understanding structural characteristics of out-of-register hIAPP amyloid proteins via molecular dynamics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.1039/c6ra19100b | - |
dc.identifier.scopusid | 2-s2.0-85024364771 | - |
dc.identifier.wosid | 000382482200060 | - |
dc.identifier.bibliographicCitation | RSC ADVANCES, v.6, no.81, pp.77666 - 77672 | - |
dc.relation.isPartOf | RSC ADVANCES | - |
dc.citation.title | RSC ADVANCES | - |
dc.citation.volume | 6 | - |
dc.citation.number | 81 | - |
dc.citation.startPage | 77666 | - |
dc.citation.endPage | 77672 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | MECHANICAL RESPONSE | - |
dc.subject.keywordPlus | BETA-SHEETS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | FIBRILS | - |
dc.subject.keywordPlus | POLYPEPTIDE | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | BETA(2)-MICROGLOBULIN | - |
dc.subject.keywordPlus | PROTOFIBRILS | - |
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