Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production
- Authors
- Lee, Ki Yong; Jeong, Eun Ju; Sung, Sang Hyun; Kim, Young Choong
- Issue Date
- 2016
- Publisher
- ACG PUBLICATIONS
- Keywords
- Stemona tuberose; alkaloids; lipopolysaccharide; BV2 microglia; nitric oxide
- Citation
- RECORDS OF NATURAL PRODUCTS, v.10, no.1, pp.109 - 112
- Indexed
- SCIE
SCOPUS
- Journal Title
- RECORDS OF NATURAL PRODUCTS
- Volume
- 10
- Number
- 1
- Start Page
- 109
- End Page
- 112
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90418
- ISSN
- 1307-6167
- Abstract
- A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 mu M.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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