Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박로빈 | - |
dc.contributor.author | 김태환 | - |
dc.contributor.author | 지종대 | - |
dc.date.accessioned | 2021-09-04T05:50:04Z | - |
dc.date.available | 2021-09-04T05:50:04Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90477 | - |
dc.description.abstract | Objective. To identify a gene expression signature in axial spondyloarthritis/ankylosing spondylitis (SpA/AS) and genomic pathways likely to be involved in pathogenesis of SpA/AS patients. Methods. Four publicly accessible microarray studies from SpA/AS patients were integrated, and a transcriptomic and network-based meta-analysis was performed. This meta-analysis was compared with a published microarray study in whole blood of AS patients. Results. According to our meta-analysis, 1,798 genes were differentially expressed in the whole blood of SpA/AS patients compared to healthy controls, while 674 genes were differentially expressed in the synovium of SpA/AS patients compared to healthy controls. When the whole blood meta-analysis data was compared with a published microarray study that also analyzed whole blood in SpA/AS patients, pathways involved in Toll-like receptor signaling, osteoclast differentiation, T cell receptor signaling and janus kinase–signal transducer and activator of transcription (Jak-STAT) signaling were often enriched in SpA/AS. On the other hand, eomesodermin, RUNX3, and interleukin- 7 receptor (IL7R) were usually decreased in SpA/AS patients, suggesting that deficiency of these genes contributes to increased IL-17 production in AS. Conclusion. Several common enrichment pathways including Toll-like receptor signaling pathway, osteoclast differentiation, T cell receptor signaling pathway and Jak-STAT signaling pathway were identified in the differentially expressed genes of whole blood and synovium from SpA/AS patients, suggesting that these pathways are involved in the pathogenesis of SpA/AS. (J Rheum Dis 2016;23:363-372) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한류마티스학회 | - |
dc.title | Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets | - |
dc.title.alternative | Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 지종대 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.23, no.6, pp.363 - 372 | - |
dc.relation.isPartOf | 대한류마티스학회지 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 363 | - |
dc.citation.endPage | 372 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002175506 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Axial spondyloarthritis | - |
dc.subject.keywordAuthor | Ankylosing spondylitis | - |
dc.subject.keywordAuthor | Microarray | - |
dc.subject.keywordAuthor | Network analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.